{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:36:27Z","timestamp":1788248187773,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T00:00:00Z","timestamp":1542412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003206","name":"Alberta Children's Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Perinatal stroke causes lifelong disability, particularly hemiparetic cerebral palsy. Arterial ischemic strokes (AIS) are large, cortical, and subcortical injuries acquired near birth due to acute occlusion of the middle cerebral artery. Periventricular venous infarctions (PVI) are smaller, subcortical strokes acquired prior to 34 weeks gestation involving injury to the periventricular white matter. Both stroke types can damage motor pathways, thus, we investigated resulting alterations in functional motor networks and probed function. We measured blood oxygen level dependent (BOLD) fluctuations at rest in 38 participants [10 arterial patients (age\u2009=\u200914.7\u2009\u00b1\u20094.1 years), 10 venous patients (age\u2009=\u200913.5\u2009\u00b1\u20093.7 years), and 18 typically developing controls (TDCs) (age\u2009=\u200915.3\u2009\u00b1\u20095.1 years)] and explored strength and laterality of functional connectivity in the motor network. Inclusion criteria included MRI\u2010confirmed, unilateral perinatal stroke, symptomatic hemiparetic cerebral palsy, and 6\u201319 years old at time of imaging. Seed\u2010based functional connectivity analyses measured temporal correlations in BOLD response over the whole brain using primary motor cortices as seeds. Laterality indices based on mean z\u2010scores in lesioned and nonlesioned hemispheres explored laterality. In AIS patients, significant differences in both strength and laterality of motor network connections were observed compared with TDCs. In PVI patients, motor networks largely resembled those of healthy controls, albeit slightly weaker and asymmetric, despite subcortical damage and hemiparesis. Functional connectivity strengths were not related to motor outcome scores for either stroke group. This study serves as a foundation to better understand how resting\u2010state fMRI can assess motor functional connectivity and potentially be applied to explore mechanisms of interventional therapies after perinatal stroke.<\/jats:p>","DOI":"10.1002\/hbm.24474","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T12:42:16Z","timestamp":1542458536000},"page":"1632-1642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Imaging functional motor connectivity in hemiparetic children with perinatal stroke"],"prefix":"10.1002","volume":"40","author":[{"given":"Jennifer","family":"Saunders","sequence":"first","affiliation":[{"name":"Neuroscience Graduate Program University of Calgary  Calgary Alberta Canada"},{"name":"Calgary Pediatric Stroke Program Alberta Children's Hospital Research Institute  Calgary Alberta 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