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MRI scans of 30 ASD, 29 patients with early\u2010onset first\u2010episode psychosis (EO\u2010FEP) and 26 typically developing controls (TD) (age range 10\u201318 years) were analyzed by the FreeSurfer suite to calculate vertex\u2010wise estimates of CT, SA, and cortical volume. Two publicly available datasets of ASD and EOP (age range 7\u201318 years and 5\u201317 years, respectively) were used for replication analysis. ASD and EO\u2010FEP had spatially overlapping areas of cortical thinning and reduced SA in the bilateral insula (all<jats:italic>p<\/jats:italic>\u2019s\u2009&lt;\u2009.00002); 37% of all left insular vertices presenting with significant cortical thinning and 20% (left insula) and 61% (right insula) of insular vertices displaying decreased SA overlapped across both disorders. In both disorders, SA deficits contributed more to cortical volume decreases than reductions in CT did. This finding, as well as the novel finding of an absence of spatial overlap (for ASD) or marginal overlap (for EOP) of deficits in CT and SA, was replicated in the two nonoverlapping independent samples. The insula appears to be a region with transdiagnostic vulnerability for deficits in CT and SA. The finding of nonexistent or small spatial overlap between CT and SA deficits in young people with ASD and psychosis may point to the involvement of common aberrant early neurodevelopmental mechanisms in their pathophysiology.<\/jats:p>","DOI":"10.1002\/hbm.24475","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T05:15:50Z","timestamp":1545282950000},"page":"1643-1653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Neuroanatomical deficits shared by youth with autism spectrum disorders and psychotic disorders"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-3175","authenticated-orcid":false,"given":"Covadonga M.","family":"D\u00edaz\u2010Caneja","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Ciber del \u00c1rea 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