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We used a large resting\u2010state fMRI (rs\u2010fMRI) sample from the PREDICT\u2010HD study (<jats:italic>N<\/jats:italic>\u2009=\u2009183 Huntington disease gene mutation carriers [HDgmc] and <jats:italic>N<\/jats:italic>\u2009=\u200978 healthy control [HC] participants) to examine whole\u2010brain dFNC and its associations with CAG repeat length as well as the product of scaled CAG length and age, a variable representing disease burden. We also tested for relationships between functional connectivity and motor and cognitive measurements. Group independent component analysis was applied to rs\u2010fMRI data to obtain whole\u2010brain resting state networks. FNC was defined as the correlation between RSN time\u2010courses. Dynamic FNC behavior was captured using a sliding time window approach, and FNC results from each window were assigned to four clusters representing FNC states, using a k\u2010means clustering algorithm. HDgmc individuals spent significantly more time in State\u20101 (the state with the weakest FNC pattern) compared to HC. However, overall HC individuals showed more FNC dynamism than HDgmc. Significant associations between FNC states and genetic and clinical variables were also identified. In FNC State\u20104 (the one that most resembled static FNC), HDgmc exhibited significantly decreased connectivity between the putamen and medial prefrontal cortex compared to HC, and this was significantly associated with cognitive performance. In FNC State\u20101, disease burden in HDgmc participants was significantly associated with connectivity between the postcentral gyrus and posterior cingulate cortex, as well as between the inferior occipital gyrus and posterior parietal cortex.<\/jats:p>","DOI":"10.1002\/hbm.24504","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T03:24:03Z","timestamp":1547004243000},"page":"1955-1968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Dynamic functional network connectivity in Huntington's disease and its associations with motor and cognitive measures"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8465-4543","authenticated-orcid":false,"given":"Flor A.","family":"Espinoza","sequence":"first","affiliation":[{"name":"Department of Translational Neuroscience, The Mind Research Network  Albuquerque New 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