{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:44:15Z","timestamp":1790387055844,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000135","name":"NIH Blueprint for Neuroscience Research","doi-asserted-by":"publisher","award":["1U54MH091657"],"award-info":[{"award-number":["1U54MH091657"]}],"id":[{"id":"10.13039\/100000135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009607","name":"McDonnell Center for Systems Neuroscience","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present study, we use resting state fMRI to investigate whether nucleus accumbens (NAc) and extended frontostriatal networks are involved in the pathology of auditory phantom perception, i.e., tinnitus, through a study of functional connectivity. We hypothesize that resting state functional connectivity involving NAc will be increased relative to what is observed in healthy subjects and that this connectivity will correlate with clinical measures of tinnitus such as percept loudness, duration of symptoms, etc. We show that a large sample of patients with chronic tinnitus (<jats:italic>n<\/jats:italic>\u2009=\u200990) features extensive functional connectivity involving NAc that is largely absent in healthy subjects (<jats:italic>n<\/jats:italic>\u2009=\u200994). We further show that connectivity involving NAc correlates significantly with tinnitus percept loudness and the duration of tinnitus symptoms, even after controlling for the effects of age and hearing loss. The loudness correlation, which involves NAc and parahippocampal cortex, is consistent with existing literature identifying the parahippocampus as a tinnitus generator. Our results further suggest that frontostriatal connectivity may predict the transition from acute to chronic tinnitus, analogous to what is seen in the pain literature. We discuss these ideas and suggest fruitful avenues for future research.<\/jats:p>","DOI":"10.1002\/hbm.24521","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T06:44:56Z","timestamp":1547621096000},"page":"2241-2251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Frontostriatal network dysfunction as a domain\u2010general mechanism underlying phantom perception"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2536-9491","authenticated-orcid":false,"given":"Jeffrey","family":"Hullfish","sequence":"first","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Abenes","sequence":"additional","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Bin","family":"Yoo","sequence":"additional","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"De Ridder","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Dunedin School of Medicine, University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Vanneste","sequence":"additional","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas"},{"name":"Global Brain Health Institute Institute of Neuroscience, Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.11.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1999)7:4<254::AID-HBM4>3.0.CO;2-G"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3576-06.2006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3153"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2007.12.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.042"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2000.10736099"},{"key":"e_1_2_8_9_1","volume-title":"Recommended procedure: Pure\u2010tone air\u2010conduction and bone\u2010conduction threshold audiometry with and without masking","author":"British Society of Audiology","year":"2017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2011.21624"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.02.019"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1252254"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2015.10.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.02.018"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460030303"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.127"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2206"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1988.tb00778.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Hochberg Y.","year":"1995","journal-title":"Journal of the Royal Statistical Society"},{"key":"e_1_2_8_21_1","volume-title":"IBM SPSS statistics for windows","author":"IBM Corp","year":"2013"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22077"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.08.037"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2015.11.004"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11527"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.12.002"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23204"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.12.012"},{"key":"e_1_2_8_29_1","first-page":"11","article-title":"Validation of the Dutch and the French version of the tinnitus questionnaire","volume":"3","author":"Meeus O.","year":"2007","journal-title":"B\u2010Ent"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.03.010"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-145-5_14"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214605109"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2016.00104"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2015.08.002"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018466108"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.04.001"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12405"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.03.021"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu097"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.07.075"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.11.046"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphysparis.2015.02.001"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.10.004"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.02.075"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.039"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.08.025"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.01.014.2008"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(87)90054-2"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.012"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07793.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.12.002"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.107"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"e_1_2_8_56_1","unstructured":"World Medical Association. (2000).Declaration of Helsinki ethical principles for medical research involving human subjects.52nd WMA General Assembly. Edinburgh Scotland."},{"key":"e_1_2_8_57_1","first-page":"53","article-title":"Functional clustering of the human inferior parietal lobule by whole\u2010brain connectivity mapping of resting\u2010state functional magnetic resonance imaging signals","volume":"4","author":"Zhang S.","year":"2014","journal-title":"Brain Connectivity"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.24521","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24521","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.24521","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T03:40:47Z","timestamp":1720928447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.24521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,15]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/hbm.24521"],"URL":"https:\/\/doi.org\/10.1002\/hbm.24521","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,15]]},"assertion":[{"value":"2018-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}