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Previous functional neuroimaging research has demonstrated the left supramarginal (SMG) exhibits functional connectivity to both ventral and dorsal pathways, supporting the integration of ventrally\u2010mediated tool properties and conceptual knowledge with dorsally\u2010computed volumetric and structural representations of tools. This architecture affords us the opportunity to test whether interactions between the left SMG, ventral visual pathway, and dorsal visual pathway are differentially modulated when participants plan and generate tool\u2010directed gestures emphasizing functional manipulation (tool use gesturing) or structure\u2010based grasping (tool transport gesturing). We found that functional connectivity between the left SMG, ventral temporal cortex (bilateral fusiform gyri), and dorsal visual pathway (left superior parietal lobule\/posterior intraparietal sulcus) was maximal for tool transport planning and gesturing, whereas functional connectivity between the left SMG, left ventral anterior temporal lobe, and left frontal operculum was maximal for tool use planning and gesturing. These results demonstrate that functional connectivity to the left SMG is differentially modulated by tool use and tool transport gesturing, suggesting that distinct tool features computed by the two object processing pathways are integrated in the parietal lobe in the service of tool\u2010directed action.<\/jats:p>","DOI":"10.1002\/hbm.24565","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T02:25:23Z","timestamp":1553221523000},"page":"2867-2883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Gesturing tool use and tool transport actions modulates inferior parietal functional connectivity with the dorsal and ventral object processing pathways"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8843-9127","authenticated-orcid":false,"given":"Frank E.","family":"Garcea","sequence":"first","affiliation":[{"name":"Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network  Elkins Park Pennsylvania"},{"name":"Cognitive Neuroscience, University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2421-5455","authenticated-orcid":false,"given":"Laurel J.","family":"Buxbaum","sequence":"additional","affiliation":[{"name":"Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network  Elkins Park Pennsylvania"},{"name":"Department of Rehabilitation Medicine Thomas Jefferson University  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.11.013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2010.21567"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00642-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2012.07.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2004.11.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2006.18.10.1644"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0597-14.2014"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617718000590"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2018.02.016"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/rev0000051"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.08.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.02.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm110"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhk022"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2017.05.018"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/13217"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0635"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx017"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2016.11.014"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx120"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu328"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135409"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2012.08.003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2004.06.013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00937"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2016.08.003"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00753"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.06.046"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2015.03.012"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00425"},{"key":"e_1_2_8_32_1","article-title":"Domain\u2010specific Diaschisis: Lesions to parietal action areas modulate neural responses to tools in the ventral stream","author":"Garcea F. 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