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Despite growing interest in PCu\/PCC functional alterations in disease and disease risk, the underlying neurochemical modulators of PCu\/PCC's task\u2010evoked activity are largely unstudied. Here, a multimodal imaging approach was applied to investigate whether interindividual differences in PCu\/PCC fMRI activity, elicited during perceptual discrimination of scene stimuli, were correlated with local brain metabolite levels, measured during resting\u2010state\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010MRS. Forty healthy young adult participants completed an fMRI perceptual odd\u2010one\u2010out task for scenes, objects and faces.\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010MRS metabolites\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010aspartate (tNAA), glutamate (Glx) and \u03b3\u2010amino\u2010butyric acid (GABA+) were quantified via PRESS and MEGA\u2010PRESS scans in a PCu\/PCC voxel and an occipital (OCC) control voxel. Whole brain fMRI revealed a cluster in right dorsal PCu\/PCC that showed a greater BOLD response to scenes versus faces and objects. When extracted from an independently defined PCu\/PCC region of interest, scene activity (vs. faces and objects and also vs. baseline) was positively correlated with PCu\/PCC, but not OCC, tNAA. A voxel\u2010wise regression analysis restricted to the PCu\/PCC\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010MRS voxel area identified a significant PCu\/PCC cluster, confirming the positive correlation between scene\u2010related BOLD activity and PCu\/PCC tNAA. There were no correlations between PCu\/PCC activity and Glx or GABA+ levels. These results demonstrate, for the first time, that scene activity in PCu\/PCC is linked to local tNAA levels, identifying a neurochemical influence on interindividual differences in the task\u2010driven activity of a key brain hub.\n                  <\/jats:p>","DOI":"10.1002\/hbm.24566","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T11:45:28Z","timestamp":1552477528000},"page":"2884-2898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Neurochemical correlates of scene processing in the precuneus\/posterior cingulate cortex: A multimodal fMRI and\n                    <sup>1<\/sup>\n                    H\u2010MRS study"],"prefix":"10.1002","volume":"40","author":[{"given":"Alison G.","family":"Costigan","sequence":"first","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre School of Psychology, Cardiff University  Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Umla\u2010Runge","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre School of Psychology, Cardiff University  Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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