{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:06:52Z","timestamp":1789063612118,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fundaci\u00f3n de investigaci\u00f3n HM Hospitales"},{"name":"Insightec","award":["ET002"],"award-info":[{"award-number":["ET002"]}]},{"name":"Spanish Ministry of Education"},{"name":"National Program Juan de la Cierva","award":["FJCI-2015-25095"],"award-info":[{"award-number":["FJCI-2015-25095"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Essential tremor is the most common movement disorder in adults. In patients who are not responsive to medical treatment, functional neurosurgery and, more recently, transcranial MR\u2010guided focused ultrasound thalamotomy are considered effective therapeutic approaches. However, the structural brain changes following a thalamotomy that mediates the clinical improvement are still unclear. In here diffusion weighted images were acquired in a cohort of 24 essential tremor patients before and 3\u2009months after unilateral transcranial MR\u2010guided focused ultrasound thalamotomy targeting at the posteroventral part of the VIM. Microstructural changes along the DRTT were quantified by means of probabilistic tractography, and later related to the clinical improvement of the patients at 3\u2010months and at 1\u2010year after the intervention. In addition the changes along two neighboring tracts, that is, the corticospinal tract and the medial lemniscus, were assessed, as well as the relation between these changes and the presence of side effects. Thalamic lesions produced local and distant alterations along the trajectory of the DRTT, and each correlated with clinical improvement. Regarding side effects, gait imbalance after thalamotomy was associated with greater impact on the DRTT, whereas the presence of paresthesias was significantly related to a higher overlap between the lesion and the medial lemniscus. This work represents the largest series describing the microstructural changes following transcranial MR\u2010guided focused ultrasound thalamotomy in essential tremor. These results suggest that clinical benefits are specific for the impact on the cerebello\u2010thalamo\u2010cortical pathway, thus reaffirming the potential of tractography to aid thalamotomy targeting.<\/jats:p>","DOI":"10.1002\/hbm.24569","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T15:45:31Z","timestamp":1552491931000},"page":"2933-2942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Microstructural changes of the dentato\u2010rubro\u2010thalamic tract after transcranial MR guided focused ultrasound ablation of the posteroventral VIM in essential tremor"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8776-0031","authenticated-orcid":false,"given":"Jose A.","family":"Pineda\u2010Pardo","sequence":"first","affiliation":[{"name":"CINAC (Centro Integral de Neurociencias) University Hospital HM Puerta del Sur, CEU\u2010San Pablo 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