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In this study, we investigated cortical and white matter (WM) MRI alterations in 25 patients with KD, compared with 24 healthy subjects, 25 patients with sporadic amyotrophic lateral sclerosis (ALS), and 35 cases with lower motor neuron\u2010predominant disease (LMND). LMND patients were clinically differentiated into 24 fast and 11 slow progressors. Whole\u2010brain cortical thickness, WM tract\u2010based spatial statistics and corticospinal tract (CST) tractography analyses were performed. No significant difference in terms of cortical thickness was found between groups. ALS patients showed widespread decreased fractional anisotropy and increased mean (MD) and radial diffusivity (radD) in the CST, corpus callosum and fronto\u2010temporal extra\u2010motor tracts, compared with healthy controls and other patient groups. CST tractography showed significant alterations of DT MRI metrics in ALS and LMND\u2010fast patients whereas KD and LMND\u2010slow patients were comparable with healthy controls. Our study demonstrated the absence of WM abnormalities in patients with KD and LMND\u2010slow, in contrast with diffuse WM damage in ALS and focal CST degeneration in LMND\u2010fast, supporting the use of DT MRI measures as powerful tools to differentiate fast\u2010 and slow\u2010progressing MND syndromes, including KD.<\/jats:p>","DOI":"10.1002\/hbm.24583","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T06:29:31Z","timestamp":1553840971000},"page":"3102-3112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Brain MRI shows white matter sparing in Kennedy's disease and slow\u2010progressing lower motor neuron disease"],"prefix":"10.1002","volume":"40","author":[{"given":"Edoardo G.","family":"Spinelli","sequence":"first","affiliation":[{"name":"Neuroimaging Research Unit Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, 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