{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:30:04Z","timestamp":1791361804649,"version":"4.3.1"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T00:00:00Z","timestamp":1557619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["APIC: 01EE1405 A\u2010C"],"award-info":[{"award-number":["APIC: 01EE1405 A\u2010C"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG IRTG 2150; MA 2631\/6\u20101"],"award-info":[{"award-number":["DFG IRTG 2150; MA 2631\/6\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2019,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mismatch responses reflect neural mechanisms of early cognitive processing in the auditory domain. Disturbances of these mechanisms on multiple levels of neural processing may contribute to clinical symptoms in major depression (MD). A functional magnetic resonance imaging (fMRI) study was conducted to identify neurobiological foundations of altered mismatch processing in MD. Twenty\u2010five patients with major depression and 25 matched healthy individuals completed an auditory mismatch paradigm optimized for fMRI. Brain activity during mismatch processing was compared between groups. Moreover, seed\u2010based connectivity analyses investigated depression\u2010specific brain networks. In patients, mismatch processing was associated with reduced activation in the right auditory cortex as well as in a fronto\u2010parietal attention network. Moreover, functional coupling between the right auditory cortex and frontal areas was reduced in patients. Seed\u2010to voxel analysis on the whole\u2010brain level revealed reduced connectivity between the auditory cortex and the thalamus as well as posterior cingulate. The present study indicates deficits in sensory processing on the level of the auditory cortex in depression. Hyposensitivity in a fronto\u2010parietal network presumably reflects altered attention mechanisms in depression. The observed impairments may contribute to psychopathology by reducing the ability of the affected individuals to orient attention toward important environmental cues.<\/jats:p>","DOI":"10.1002\/hbm.24623","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T05:33:11Z","timestamp":1557725591000},"page":"3657-3668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Fronto\u2010parietal and temporal brain dysfunction in depression: A fMRI investigation of auditory mismatch processing"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-1054","authenticated-orcid":false,"given":"Jana","family":"Zweerings","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine RWTH Aachen University  Aachen Germany"},{"name":"Institute for Neuroscience and Medicine (INM\u201010): JARA Institute Brain Structure Function Research Center J\u00fclich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9521-042X","authenticated-orcid":false,"given":"Mikhail","family":"Zvyagintsev","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine RWTH Aachen University  Aachen Germany"},{"name":"Institute for Neuroscience and Medicine (INM\u201010): JARA Institute Brain Structure Function Research Center J\u00fclich  J\u00fclich Germany"},{"name":"Brain Imaging Facility, Interdisciplinary Centre for Clinical Studies (IZKF) School of Medicine, RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce I.","family":"Turetsky","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Section, Department of Psychiatry University of Pennsylvania, Perelman School of Medicine  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Klasen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine RWTH Aachen University  Aachen Germany"},{"name":"Institute for Neuroscience and Medicine (INM\u201010): JARA Institute Brain Structure Function Research Center J\u00fclich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Roecher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine RWTH Aachen University  Aachen Germany"},{"name":"Institute for Neuroscience and Medicine (INM\u201010): JARA Institute Brain Structure Function Research Center J\u00fclich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnim J.","family":"Gaebler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine RWTH Aachen University  Aachen Germany"},{"name":"Institute for Neuroscience and Medicine (INM\u201010): JARA Institute Brain Structure Function Research Center J\u00fclich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Mathiak","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine RWTH Aachen University  Aachen Germany"},{"name":"Institute for Neuroscience and Medicine (INM\u201010): JARA Institute Brain Structure Function Research Center J\u00fclich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04674.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199502000-00004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.11.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.06.034"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.07.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0560-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.100560"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.02.009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.11.049"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00389-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-013-0328-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.06.045"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv049"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.11.029"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.10.008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.12.021"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2005.11.011"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13121691"},{"issue":"5","key":"e_1_2_9_20_1","first-page":"316","article-title":"Dysfunction in early auditory processing in major depressive disorder revealed by combined MEG and EEG","volume":"32","author":"K\u00e4hk\u00f6nen S.","year":"2007","journal-title":"Journal of Psychiatry & Neuroscience : JPN"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0071"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.2.294"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.3.1270"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.10.023"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.09.042"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10041"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.04.022"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3628"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh155"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.01.028"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1176"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2011.06.006"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199502000-00002"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0511(79)90053-X"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2003.04.001"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-014-0374-6"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.12.028"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0970"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/10673220216210"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091995"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.11.042"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn162"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.104"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.07.006"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0591"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-12-32"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2008.00748.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2007.10.009"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2005.09.003"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01642-6"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109102606"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.12.058"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.24623","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24623","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.24623","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T20:37:38Z","timestamp":1694291858000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.24623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,12]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,8,15]]}},"alternative-id":["10.1002\/hbm.24623"],"URL":"https:\/\/doi.org\/10.1002\/hbm.24623","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,12]]},"assertion":[{"value":"2018-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}