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Total hippocampal volume and volume of eight bilateral subfields were measured using FreeSurfer software. Subregional shape deformity was examined via FSL software. Volumetric and shape differences between groups and correlations with OCD symptoms were examined. The volume of right hippocampus was significantly reduced in OCD patients (<jats:italic>p<\/jats:italic> = .001, \u03b7<jats:sup>2<\/jats:sup> = 0.065). Follow\u2010up analysis of right hemisphere subfields showed reduced volume in right subiculum (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, \u03b7<jats:sup>2<\/jats:sup> = 0.081), presubiculum (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, \u03b7<jats:sup>2<\/jats:sup> = 0.125), CA2\/3 (<jats:italic>p<\/jats:italic> = .001, \u03b7<jats:sup>2<\/jats:sup> = 0.06), and hippocampal tail (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, \u03b7<jats:sup>2<\/jats:sup> = 0.105), while the volume of right fimbria was increased (<jats:italic>p<\/jats:italic> = .001, \u03b7<jats:sup>2<\/jats:sup> = 0.058). Shape analysis revealed a bilateral outward bending in the hippocampal body related to a lateral displacement of hippocampus from the body to the tail. Symptom severity was correlated with volumes of presubiculum (with compulsions, r = \u22120.25, <jats:italic>p<\/jats:italic> = .024) and fimbria (with obsessions, r = \u22120.28, <jats:italic>p<\/jats:italic> = .012), and with the lateral shift of middle and posterior hippocampus (with obsessions). Alterations across hippocampal subfields and overall shape may contribute to the distinctive cognitive and affective abnormalities associated with OCD.<\/jats:p>","DOI":"10.1002\/hbm.24688","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T13:49:05Z","timestamp":1560347345000},"page":"4105-4113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Abnormalities of hippocampal shape and subfield volumes in medication\u2010free patients with obsessive\u2013compulsive disorder"],"prefix":"10.1002","volume":"40","author":[{"given":"Lianqing","family":"Zhang","sequence":"first","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University  Chengdu China"},{"name":"Psychoradiology Research Unit of the Chinese Academy of Medical Sciences (2018RU011) West China Hospital of Sichuan University, Chengdu  Sichuan 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