{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:16:45Z","timestamp":1776183405033,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001922","name":"Efficacy and Mechanism Evaluation Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001922","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000381","name":"Multiple Sclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","award":["307098"],"award-info":[{"award-number":["307098"]}],"id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203139\/Z\/16\/Z"],"award-info":[{"award-number":["203139\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000073","name":"Autism Speaks","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000073","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate whether the observed anisotropic diffusion in cerebral cortex may reflect its columnar cytoarchitecture and myeloarchitecture, as a potential biomarker for disease\u2010related changes, we compared postmortem diffusion magnetic resonance imaging scans of nine multiple sclerosis brains with histology measures from the same regions. Histology measurements assessed the cortical minicolumnar structure based on cell bodies and associated axon bundles in dorsolateral prefrontal cortex (Area 9), Heschl's gyrus (Area 41), and primary visual cortex (V1). Diffusivity measures included mean diffusivity, fractional anisotropy of the cortex, and three specific measures that may relate to the radial minicolumn structure: the angle of the principal diffusion direction in the cortex, the component that was perpendicular to the radial direction, and the component that was parallel to the radial direction. The cellular minicolumn microcircuit features were correlated with diffusion angle in Areas 9 and 41, and the axon bundle features were correlated with angle in Area 9 and to the parallel component in V1 cortex. This may reflect the effect of minicolumn microcircuit organisation on diffusion in the cortex, due to the number of coherently arranged membranes and myelinated structures. Several of the cortical diffusion measures showed group differences between MS brains and control brains. Differences between brain regions were also found in histology and diffusivity measurements consistent with established regional variation in cytoarchitecture and myeloarchitecture. Therefore, these novel measures may provide a surrogate of cortical organisation as a potential biomarker, which is particularly relevant for detecting regional changes in neurological disorders.<\/jats:p>","DOI":"10.1002\/hbm.24711","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T13:15:12Z","timestamp":1564406112000},"page":"4417-4431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Relating diffusion tensor imaging measurements to microstructural quantities in the cerebral cortex in multiple sclerosis"],"prefix":"10.1002","volume":"40","author":[{"given":"Rebecca","family":"McKavanagh","sequence":"first","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Torso","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Jenkinson","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Kolasinski","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte J.","family":"Stagg","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret M.","family":"Esiri","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"McNab","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Johansen\u2010Berg","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6060-3805","authenticated-orcid":false,"given":"Steven A.","family":"Chance","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.06.058"},{"key":"e_1_2_10_3_1","first-page":"109","article-title":"In vivo measurement of cortical anisotropy by diffusion\u2010weighted imaging correlates with cortex type","volume":"18","author":"Anwander A.","year":"2010","journal-title":"Proceedings of the International Society for Magnetic Resonance in Medicine"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr277"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013699998"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf110"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047253"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.3.428"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.10.024"},{"key":"e_1_2_10_11_1","first-page":"161","volume-title":"Neocortical modularity and the cell minicolumn","author":"Casanova M. F.","year":"2005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn211"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-0014-z"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq264"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-012-0464-8"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.06.041"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.053"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.02.039"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2008.04.007"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.01.028"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","unstructured":"Dyrby T. B. Baare W. F. Alexander D. C. Jelsing J. Garde E. Sogaard L. V. (2011). An ex vivo imaging pipeline for producing high\u2010quality and high\u2010resolution diffusion\u2010weighted imaging datasets.Human Brain Mapping 32(4) 544\u2013563.","DOI":"10.1002\/hbm.21043"},{"issue":"8","key":"e_1_2_10_22_1","first-page":"1313","article-title":"Cytoarchitecture of the human cerebral cortex: MR microscopy of excised specimens at 9.4 tesla","volume":"23","author":"Fatterpekar G. M.","year":"2002","journal-title":"American Journal of Neuroradiology"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000036271.49066.06"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/13576500244000175"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3282f0d40c"},{"key":"e_1_2_10_26_1","unstructured":"Heidemann R. M. Anwander A. Feiweier T. Eichner C. L\u00fctzkendorf R. Bernarding J. &Turner R.(2012).Sub\u2010millimeter diffusion MRI at 7T: Does resolution matter?(Vol. 20 p. 2804)."},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","unstructured":"Heidemann R. M. Anwander A. Kn\u00f6sche T. R. Feiweier T. Fasano F. Pfeuffer J. &Turner R.(2009).High Resolution Diffusion\u2010Weighted Imaging Showing Radial Anisotropy in the Human Cortex In Vivo(Vol. 17 p. 2403). In ISMRM Annual Meeting.","DOI":"10.1016\/S1053-8119(09)70455-0"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs241"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.05.082"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2011.2162099"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.04.004"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20823"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.11.015"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws242"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.09.021"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs311"},{"key":"e_1_2_10_37_1","first-page":"2371","article-title":"Visualization of the orientational structure of the human stria of Gennari with high\u2010resolution DWI","volume":"19","author":"Leuze C. W.","year":"2011","journal-title":"Proceedings of the International Society for Magnetic Resonance in Medicine"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv110"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.008"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.11.065"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.054"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.03.070"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.08.012"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.4.701"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1205"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz143"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(97)00050-2"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.098"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21487"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90995-1"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26653"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21977"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.05.023"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1267"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.057"},{"key":"e_1_2_10_57_1","volume-title":"R: A language and environment for statistical computing","author":"Team, R. C","year":"2013"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-4-19"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.012"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-012-0381-x"},{"key":"e_1_2_10_61_1","volume-title":"Die cytoarchitektonik der hirnrinde des erwachsenen menschen","author":"Economo C. F.","year":"1925"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20564"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000237551.26858.39"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.055"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24711","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.24711","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:13:33Z","timestamp":1694240013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.24711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,29]]},"references-count":63,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2019,10,15]]}},"alternative-id":["10.1002\/hbm.24711"],"URL":"https:\/\/doi.org\/10.1002\/hbm.24711","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,29]]},"assertion":[{"value":"2019-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}