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A common denominator of the neural network underlying the integration of sensory clues has yet to be identified. Additionally, brain imaging data from patients with autism spectrum disorder (ASD) do not cover disparities in neuronal sensory processing. In this fMRI study, we compared the underlying neural networks of both olfactory\u2013visual and auditory\u2013visual integration in patients with ASD and a group of matched healthy participants. The aim was to disentangle sensory\u2010specific networks so as to derive a potential (amodal) common source of multisensory integration (MSI) and to investigate differences in brain networks with sensory processing in individuals with ASD. In both groups, similar neural networks were found to be involved in the olfactory\u2013visual and auditory\u2013visual integration processes, including the primary visual cortex, the inferior parietal sulcus (IPS), and the medial and inferior frontal cortices. Amygdala activation was observed specifically during olfactory\u2013visual integration, with superior temporal activation having been seen during auditory\u2013visual integration. A dynamic causal modeling analysis revealed a nonlinear top\u2010down IPS modulation of the connection between the respective primary sensory regions in both experimental conditions and in both groups. Thus, we demonstrate that MSI has shared neural sources across olfactory\u2013visual and audio\u2013visual stimulation in patients and controls. The enhanced recruitment of the IPS to modulate changes between areas is relevant to sensory perception. Our results also indicate that, with respect to MSI processing, adults with ASD do not significantly differ from their healthy counterparts.<\/jats:p>","DOI":"10.1002\/hbm.24715","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T14:25:23Z","timestamp":1563027923000},"page":"4470-4486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Audio\u2013visual and olfactory\u2013visual integration in healthy participants and subjects with autism spectrum disorder"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5631-5667","authenticated-orcid":false,"given":"Susanne","family":"Stickel","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics Faculty of Medicine, RWTH Aachen  Aachen Germany"},{"name":"Institute of Neuroscience and Medicine: JARA\u2010Institute Brain Structure Function Relationship (INM 10) 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