{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:32:19Z","timestamp":1790451139886,"version":"4.1.0"},"reference-count":99,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aberrations of large\u2010scale brain networks are found in the majority of neurodegenerative disorders. The brain connectivity alterations underlying dementia with Lewy bodies (DLB) remain, however, still elusive, with contrasting results possibly due to the pathological and clinical heterogeneity characterizing this disorder. Here, we provide a molecular assessment of brain network alterations, based on cerebral metabolic measurements as proxies of synaptic activity and density, in a large cohort of DLB patients (<jats:italic>N<\/jats:italic> = 72). We applied a seed\u2010based interregional correlation analysis approach (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01, false discovery rate corrected) to evaluate large\u2010scale resting\u2010state networks' integrity and their interactions. We found both local and long\u2010distance metabolic connectivity alterations, affecting the posterior cortical networks, that is, primary visual and the posterior default mode network, as well as the limbic and attention networks, suggesting a widespread derangement of the brain connectome. Notably, patients with the lowest visual and attention cognitive scores showed the most severe connectivity derangement in regions of the primary visual network. In addition, network\u2010level alterations were differentially associated with the core clinical manifestations, namely, hallucinations with more severe metabolic dysfunction of the attention and visual networks, and rapid eye movement sleep behavior disorder with alterations of connectivity of attention and subcortical networks. These multiple network\u2010level vulnerabilities may modulate the core clinical and cognitive features of DLB and suggest that DLB should be considered as a complex multinetwork disorder.<\/jats:p>","DOI":"10.1002\/hbm.24719","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T11:12:35Z","timestamp":1563534755000},"page":"4537-4550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Vulnerability of multiple large\u2010scale brain networks in dementia with Lewy bodies"],"prefix":"10.1002","volume":"40","author":[{"given":"Arianna","family":"Sala","sequence":"first","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"In Vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4568-1738","authenticated-orcid":false,"given":"Silvia Paola","family":"Caminiti","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"In Vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Iaccarino","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"In Vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Beretta","sequence":"additional","affiliation":[{"name":"In Vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Iannaccone","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience Department San Raffaele Turro Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Magnani","sequence":"additional","affiliation":[{"name":"Department of Neurology IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Padovani","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferini\u2010Strambi","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"Department of Clinical Neurosciences San Raffaele Scientific Institute, Neurology, Sleep Disorders Center  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3421-204X","authenticated-orcid":false,"given":"Daniela","family":"Perani","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"In Vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Nuclear Medicine Unit IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","article-title":"A resting state fMRI analysis pipeline for pooling inference across diverse cohorts: An ENIGMA rs\u2010fMRI protocol","author":"Adhikari B. M.","year":"2018","journal-title":"Brain Imaging and Behavior"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.2.462"},{"key":"e_1_2_9_4_1","volume-title":"International classification of sleep disorders","author":"American Academy of Sleep Medicine","year":"2014"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23305"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001171"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsp053"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1776-08.2008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3475"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304095"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13269"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0473-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16654497"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4144"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X05000130"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.07.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-014-9235-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0086"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.034"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3222"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.004"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-015-9434-0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.09.015"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.23736\/S1824-4785.16.02749-7","article-title":"The impact of different 18FDG PET healthy subject scans for comparison with single patient in SPM analysis","volume":"61","author":"Gallivanone F.","year":"2017","journal-title":"The Quarterly Journal of Nuclear Medicine and Molecular Imaging"},{"key":"e_1_2_9_27_1","first-page":"1797","article-title":"Resting bold fMRI differentiates dementia with Lewy bodies vs. Alzheimer's disease","volume":"76","author":"Galvin J.","year":"2011","journal-title":"Alzheimer's Dementia"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2198-5"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt152"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000734"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0012949"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf033"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826c1b0a"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1984.73"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151000"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2018.06.014"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.106.035691"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0016792"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318233b33d"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.07.010"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.09.024"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8751"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr327"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.108464"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d55f61"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2017.02.016"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2010.04.008"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.5.477"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-008-0808-z"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.184747"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221536110"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1392-5"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2014.06.004"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.11.2117"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1133"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30074-1"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.10.009"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1610909114"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.03.013"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.05.015"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2009.08.001"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132084"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.178"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww124"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00617"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04102-z"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5108-12.2013"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2573"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322121"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.185835"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.10.009"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23901"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a023622"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.03.024"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3335-10.2011"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2014.01.004"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1162\/netn_a_00042"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr099"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2016.00060"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.05.020"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27018"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.08.005"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23291"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq268"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17708692"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-008-9055-0"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.03.008"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.09.012"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1264-0"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0414-12.2012"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.08.072"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.006"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.06.007"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4481"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.24719","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:15:50Z","timestamp":1694240150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.24719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,19]]},"references-count":99,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2019,10,15]]}},"alternative-id":["10.1002\/hbm.24719"],"URL":"https:\/\/doi.org\/10.1002\/hbm.24719","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,19]]},"assertion":[{"value":"2019-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}