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However, little is known about the topological organization of brain white matter networks in posttraumatic stress disorder (PTSD). Seventy\u2010six patients with PTSD and 76 age, gender, and years of education\u2010matched trauma\u2010exposed controls were studied after the 2008 Sichuan earthquake using diffusion tensor imaging and graph theoretical approaches. Topological properties of brain networks including global and nodal measurements and modularity were analyzed. At the global level, patients showed lower clustering coefficient (<jats:italic>p<\/jats:italic> = .016) and normalized characteristic path length (<jats:italic>p<\/jats:italic> = .035) compared with controls. At the nodal level, increased nodal centralities in left middle frontal gyrus, superior and inferior temporal gyrus and right inferior occipital gyrus were observed (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05, corrected for false\u2010discovery rate). Modularity analysis revealed that PTSD patients had significantly increased inter\u2010modular connections in the fronto\u2010parietal module, fronto\u2010striato\u2010temporal module, and visual and default mode modules. These findings indicate a PTSD\u2010related shift of white matter network topology toward randomization. This pattern was characterized by an increased global network integration, reflected by increased inter\u2010modular connections with increased nodal centralities involving fronto\u2010temporo\u2010occipital regions. This study suggests that extremely stressful life experiences, when they lead to PTSD, are associated with large\u2010scale brain white matter network topological reconfiguration at global, nodal, and modular levels.<\/jats:p>","DOI":"10.1002\/hbm.24738","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T13:55:07Z","timestamp":1564581307000},"page":"4801-4812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Large\u2010scale white matter network reorganization in posttraumatic stress disorder"],"prefix":"10.1002","volume":"40","author":[{"given":"Xueling","family":"Suo","sequence":"first","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"Lei","sequence":"additional","affiliation":[{"name":"Huaxi MR Research 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