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Furthermore, specific topological alterations in functional networks and their role in behavioral inhibition dysfunction remain to be established. Resting\u2010state functional magnetic resonance imaging was performed on 51 drug\u2010na\u00efve children with ADHD and 55 age\u2010matched healthy controls. Brain functional networks were constructed by thresholding the partial correlation matrices of 90 brain regions, and graph theory was used to analyze network topological properties. The Stroop test was used to assess cognitive inhibitory abilities. Nonparametric permutation tests were used to compare the topological architectures in the two groups. Compared with healthy subjects, brain networks in ADHD patients demonstrated altered topological characteristics, including lower global (FDR <jats:italic>q<\/jats:italic> = 0.01) and local efficiency (<jats:italic>p<\/jats:italic> = 0.032, uncorrected) and a longer path length (FDR <jats:italic>q<\/jats:italic> = 0.01). Lower nodal efficiencies were found in the left inferior frontal gyrus and anterior cingulate cortex in the ADHD group (FDR both <jats:italic>q<\/jats:italic>\u2009&lt;\u20090.05). Altered global and nodal topological efficiencies were associated with the severity of inhibitory cognitive control deficits and hyperactivity symptoms in ADHD (<jats:italic>p<\/jats:italic>\u2009&lt;0\u2009.05). Alterations in network topologies in drug\u2010na\u00efve ADHD patients indicate weaker small\u2010worldization with decreased segregation and integration of functional brain networks. Deficits in the cingulo\u2010fronto\u2010parietal attention network were associated with inhibitory control deficits.<\/jats:p>","DOI":"10.1002\/hbm.24743","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T12:59:50Z","timestamp":1564491590000},"page":"4877-4887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Disrupted brain functional networks in drug\u2010na\u00efve children with attention deficit hyperactivity disorder assessed using graph theory analysis"],"prefix":"10.1002","volume":"40","author":[{"given":"Ying","family":"Chen","sequence":"first","affiliation":[{"name":"Huaxi MR Research Center (HMRRC) Department of Radiology, West China Hospital of Sichuan University  Chengdu China"},{"name":"Department of Psychiatry West China Hospital of Sichuan University  Chengdu 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