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To identify the possible roles of these circuits in the alcohol\u2010sleep association, we investigated the volume of both left and right thalamus and corresponding resting\u2010state functional connectivity (RSFC) differences between 15 alcohol\u2010dependent patients (AD) and 15 healthy controls (HC) male participants. The neuroimaging findings were then correlated with clinical variables, that is, Alcohol Use Disorders Identification Test (AUDIT) and Pittsburgh Sleep Quality Index (PSQI). Additionally, mediation analysis was carried out to test whether the thalamocortical RSFC mediates the relationship between drinking behavior and sleep impairments in AD when applicable. We observed a significant positive correlation between AUDIT score and PSQI score in AD. Compared with HC, AD showed reduced RSFC between the left thalamus and medial prefrontal cortex (mPFC), orbitofrontal cortex, anterior cingulate cortex (ACC), and right caudate. We also observed a negative correlation between RSFC of the left thalamus\u2013mPFC and PSQI score in AD. More importantly, the left thalamus\u2013mPFC RSFC strength mediated the relationship between AUDIT score and PSQI score in AD. No significant difference was detected in the normalized volume of both left and right thalamus, and volumes were not significantly correlated with clinical variables. Our results demonstrate that AD show abnormal interactions within thalamocortical circuits in association with drinking behaviors and sleep impairments. It is hoped that our study focusing on thalamocortical circuits could provide new information on potential novel therapeutic targets for treatment of sleep impairment in alcohol\u2010dependent patients.<\/jats:p>","DOI":"10.1002\/hbm.24749","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T06:21:00Z","timestamp":1564986060000},"page":"4941-4951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Reduced resting\u2010state functional connectivity and sleep impairment in abstinent male alcohol\u2010dependent patients"],"prefix":"10.1002","volume":"40","author":[{"given":"Jingjing","family":"Liu","sequence":"first","affiliation":[{"name":"School of Life Science and Technology Xidian University  Xi'an Shaanxi People's Republic of China"},{"name":"Engineering Research Center of Molecular and Neuro Imaging Ministry of Education  Xi'an People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanye","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University  Xi'an Shaanxi People's Republic of China"},{"name":"Engineering Research Center of Molecular and Neuro Imaging Ministry of Education  Xi'an People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University  Xi'an Shaanxi People's Republic of China"},{"name":"Engineering Research Center of Molecular and Neuro Imaging Ministry of Education  Xi'an People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Cai","sequence":"additional","affiliation":[{"name":"Xilinguole Meng Mongolian General Hospital  Xilinhaote Inner Mongolian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Sui","sequence":"additional","affiliation":[{"name":"Xilinguole Meng Mongolian General Hospital  Xilinhaote Inner Mongolian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbao","family":"Hou","sequence":"additional","affiliation":[{"name":"Xilinguole Meng Mongolian General Hospital  Xilinhaote Inner Mongolian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongde","family":"Wang","sequence":"additional","affiliation":[{"name":"Xilinguole Meng Mongolian General Hospital  Xilinhaote Inner Mongolian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7850-7512","authenticated-orcid":false,"given":"Dahua","family":"Yu","sequence":"additional","affiliation":[{"name":"Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering Inner Mongolia University of Science and Technology  Baotou Inner Mongolia People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3098-1124","authenticated-orcid":false,"given":"Kai","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University  Xi'an Shaanxi People's Republic of China"},{"name":"Engineering Research Center of Molecular and Neuro Imaging Ministry of Education  Xi'an People's Republic of China"},{"name":"Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering Inner Mongolia University of Science and Technology  Baotou Inner Mongolia People's Republic of China"},{"name":"Guangxi Key Laboratory of Multi\u2010Source Information Mining and Security Guangxi Normal University  Guilin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14100"},{"key":"e_1_2_8_3_1","volume-title":"The alcohol use disorders identification test (AUDIT): Guidelines for use in primary care","author":"Babor T. 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