{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:09:04Z","timestamp":1790780944851,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01 NS102038"],"award-info":[{"award-number":["U01 NS102038"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurite orientation dispersion and density imaging (NODDI) uses a three\u2010compartment model to probe brain tissue microstructure, whereas free\u2010water (FW) imaging models two\u2010compartments. It is unknown if NODDI detects more disease\u2010specific effects related to neurodegeneration in Parkinson's disease (PD) and atypical Parkinsonism. We acquired multi\u2010 and single\u2010shell diffusion imaging at 3 Tesla across two sites. NODDI (using multi\u2010shell; isotropic volume [Viso]; intracellular volume [Vic]; orientation dispersion [ODI]) and FW imaging (using single\u2010shell; FW; free\u2010water corrected fractional anisotropy [FAt]) were compared with 44 PD, 21 multiple system atrophy Parkinsonian variant (MSAp), 26 progressive supranuclear palsy (PSP), and 24 healthy control subjects in the basal ganglia, midbrain\/thalamus, cerebellum, and corpus callosum. There was elevated Viso in posterior substantia nigra across Parkinsonisms, and Viso, Vic, and ODI were altered in MSAp and PSP in the striatum, globus pallidus, midbrain, thalamus, cerebellum, and corpus callosum relative to controls. The mean effect size across regions for Viso was 0.163, ODI 0.131, Vic 0.122, FW 0.359, and FAt 0.125, with extracellular compartments having the greatest effect size. A key question addressed was if these techniques discriminate PD and atypical Parkinsonism. Both NODDI (AUC: 0.945) and FW imaging (AUC: 0.969) had high accuracy, with no significant difference between models. This study provides new evidence that NODDI and FW imaging offer similar discriminability between PD and atypical Parkinsonism, and FW had higher effect sizes for detecting Parkinsonism within regions across the basal ganglia and cerebellum.<\/jats:p>","DOI":"10.1002\/hbm.24760","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T09:50:44Z","timestamp":1565603444000},"page":"5094-5107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Neurite orientation dispersion and density imaging (NODDI) and free\u2010water imaging in Parkinsonism"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0442-9985","authenticated-orcid":false,"given":"Trina","family":"Mitchell","sequence":"first","affiliation":[{"name":"Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-0785","authenticated-orcid":false,"given":"Derek B.","family":"Archer","sequence":"additional","affiliation":[{"name":"Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston T.","family":"Chu","sequence":"additional","affiliation":[{"name":"Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology University of Florida  Gainesville Florida"},{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Coombes","sequence":"additional","affiliation":[{"name":"Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology &amp; CTSI Human Imaging Core University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Wilkes","sequence":"additional","affiliation":[{"name":"Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus R.","family":"McFarland","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Movement Disorders and Neurorestoration College of Medicine, University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Okun","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Movement Disorders and Neurorestoration College of Medicine, University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieniecia L.","family":"Black","sequence":"additional","affiliation":[{"name":"Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Herschel","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Human Movement Sciences Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Simuni","sequence":"additional","affiliation":[{"name":"Department of Neurology Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Comella","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Rush University Medical Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Chicago Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Medical College of South Carolina  Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1184-1572","authenticated-orcid":false,"given":"Todd B.","family":"Parrish","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay S.","family":"Kurani","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Corcos","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Human Movement Sciences Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5663-6476","authenticated-orcid":false,"given":"David E.","family":"Vaillancourt","sequence":"additional","affiliation":[{"name":"Laboratory for Rehabilitation Neuroscience, Department of Applied Physiology and Kinesiology University of Florida  Gainesville Florida"},{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida  Gainesville Florida"},{"name":"Department of Neurology and Center for Movement Disorders and Neurorestoration College of Medicine, University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.02.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm301"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.02.046"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx338"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26471"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25749"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx146"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv114"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009258"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199601000-00006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.5.2283"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1556"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21198"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm032"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5545"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh596"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6415"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.104075"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-4066-8"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23628"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0494-0"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22583"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0850"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21614"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v028.i05"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00863"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.02.056"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-014-1473-5"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3979-14.2015"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl166"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27100"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.10.029"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22055"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22440"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq212"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv361"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.11.008"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.12.005"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.12.006"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000068011.21396.F4"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-012-1009-9"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120203"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20255"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.01.007"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23917"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.084"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.072"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.07.032"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.24760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.24760","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T13:56:21Z","timestamp":1694181381000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.24760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,12]]},"references-count":54,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/hbm.24760"],"URL":"https:\/\/doi.org\/10.1002\/hbm.24760","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,12]]},"assertion":[{"value":"2019-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}