{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:18:15Z","timestamp":1787671095733,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS098494\u201003S1A1"],"award-info":[{"award-number":["R01 NS098494\u201003S1A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH 01 R01 NS098494\u201001A1"],"award-info":[{"award-number":["NIH 01 R01 NS098494\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2019,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although much attention has been generated in popular media regarding the deleterious effects of pediatric mild traumatic brain injury (pmTBI), a paucity of empirical evidence exists regarding the natural course of biological recovery. Fifty pmTBI patients (12\u201318\u2009years old) were consecutively recruited from Emergency Departments and seen approximately 1\u2009week and 4\u2009months post\u2010injury in this prospective cohort study. Data from 53 sex\u2010 and age\u2010matched healthy controls (HC) were also collected. Functional magnetic resonance imaging was obtained during proactive response inhibition and at rest, in conjunction with independent measures of resting cerebral blood flow. High temporal resolution imaging enabled separate modeling of neural responses for preparation and execution of proactive response inhibition. A priori predictions of failed inhibitory responses (i.e., hyperactivation) were observed in motor circuitry (pmTBI&gt;HC) and sensory areas sub\u2010acutely and at 4\u2009months post\u2010injury. Paradoxically, pmTBI demonstrated hypoactivation (HC&gt;pmTBI) during target processing, along with decreased activation within prefrontal cognitive control areas. Functional connectivity within motor circuitry at rest suggested that deficits were limited to engagement during the inhibitory task, whereas normal resting cerebral perfusion ruled out deficits in basal perfusion. In conclusion, current results suggest blood oxygen\u2010level dependent deficits during inhibitory control may exceed commonly held beliefs about physiological recovery following pmTBI, potentially lasting up to 4\u2009months post\u2010injury.<\/jats:p>","DOI":"10.1002\/hbm.24778","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T07:04:26Z","timestamp":1566975866000},"page":"5370-5381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Proactive inhibition deficits with normal perfusion after pediatric mild traumatic brain injury"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2396-5609","authenticated-orcid":false,"given":"Andrew R.","family":"Mayer","sequence":"first","affiliation":[{"name":"The Mind Research Network\/LBERI  Albuquerque New Mexico"},{"name":"Department of Psychology University of New Mexico  Albuquerque New Mexico"},{"name":"Department of Neurology University of New Mexico  Albuquerque New Mexico"},{"name":"Department of Psychiatry University of New Mexico  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"The Mind Research Network\/LBERI  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Wertz","sequence":"additional","affiliation":[{"name":"The Mind Research Network\/LBERI  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B.","family":"Dodd","sequence":"additional","affiliation":[{"name":"The Mind Research Network\/LBERI  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Shaff","sequence":"additional","affiliation":[{"name":"The Mind Research Network\/LBERI  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef M.","family":"Ling","sequence":"additional","affiliation":[{"name":"The Mind Research Network\/LBERI  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Park","sequence":"additional","affiliation":[{"name":"Emergency Medicine University of New Mexico  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Oglesbee","sequence":"additional","affiliation":[{"name":"Emergency Medicine University of New Mexico  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben C.","family":"Wasserott","sequence":"additional","affiliation":[{"name":"The Mind Research Network\/LBERI  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy B.","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical College of Wisconsin  Milwaukee Wisconsin"},{"name":"Department of Cell Biology Neurobiology and Anatomy, Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Witkiewitz","sequence":"additional","affiliation":[{"name":"Department of Psychology University of New Mexico  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of New Mexico  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald A.","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Psychology University of New Mexico  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Phillips","sequence":"additional","affiliation":[{"name":"The Mind Research Network\/LBERI  Albuquerque New Mexico"},{"name":"Department of Neurology University of New Mexico  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davin K.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of New Mexico  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Pottenger","sequence":"additional","affiliation":[{"name":"Emergency Medicine University of New Mexico  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.2.0167"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25197"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00336-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617711000907"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2016.01.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4634"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.05.102"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.12.010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr161"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2016.0475"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.11.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07584.x"},{"key":"e_1_2_9_15_1","article-title":"A review of traumatic brain injury animal models: Are we lacking adequate models replicating chronic traumatic encephalopathy","volume":"2","author":"Galgano M.","year":"2015","journal-title":"Journal of Neurology and Neurobiology"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2009.058255"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0419"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617713000702"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/02699050701528454"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071013-014111"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.05.009"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.4.4.045007"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3052"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854040701543700"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usx184"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617711001226"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01044.2011"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2012.04414.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510392326"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2083"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.150097"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.08.002"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24635"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3379-12.2012"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21151"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5340"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws307"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4778"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21785"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.2883"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.151"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-71512-2_16"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.10.044"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0881-z"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400178111"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2016.11.011"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2461"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5237"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3284"},{"key":"e_1_2_9_51_1","volume-title":"Co\u2010planar stereotaxic atlas of the human brain","author":"Talairach J.","year":"1988"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2351031663"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2395"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.1082"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1056"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.10.067"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.24778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.24778","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T03:28:11Z","timestamp":1694230091000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.24778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,28]]},"references-count":55,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2019,12,15]]}},"alternative-id":["10.1002\/hbm.24778"],"URL":"https:\/\/doi.org\/10.1002\/hbm.24778","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,28]]},"assertion":[{"value":"2019-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}