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A systematic literature review was conducted in three online databases according to PRISMA guidelines, using keywords for HD, functional connectivity, and rs\u2010fMRI. We included studies investigating connectivity in presymptomatic (pre\u2010HD) and manifest HD gene carriers compared to healthy controls, implementing seed\u2010based connectivity, independent component analysis, regional property, and graph analysis approaches. Visual network showed reduced connectivity in manifest HD, while network\/areas underpinning motor functions were consistently altered in both manifest HD and pre\u2010HD, showing disease stage\u2010dependent changes. Cognitive networks underlying executive and attentional functions showed divergent anterior\u2013posterior alterations, possibly reflecting compensatory mechanisms. The involvement of these networks in pre\u2010HD is still unclear. In conclusion, aberrant connectivity of the sensory\u2010motor network is observed in the early stage of HD while, as pathology spreads, other networks might be affected, such as the visual and executive\/attentional networks. Moreover, sensory\u2010motor and executive networks exhibit hyper\u2010 and hypo\u2010connectivity patterns following different spatiotemporal trajectories. These findings could potentially help to implement future huntingtin\u2010lowering interventions.<\/jats:p>","DOI":"10.1002\/hbm.24790","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T07:34:10Z","timestamp":1568792050000},"page":"256-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Aberrant brain network connectivity in presymptomatic and manifest Huntington's disease: A systematic review"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-3376","authenticated-orcid":false,"given":"Lorenzo","family":"Pini","sequence":"first","affiliation":[{"name":"Department of Neuroscience &amp; Padova Neuroscience Center University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Jacquemot","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Etudes Cognitives Ecole Normale Sup\u00e9rieure\u2010PSL University  Paris France"},{"name":"Laboratoire de NeuroPsychologie Interventionnelle Institut Mondor de Recherche Biom\u00e9dicale, Institut National de la Sant\u00e9 et Recherche M\u00e9dical (INSERM) U955, Equipe 01  Cr\u00e9teil France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 Paris Est Cr\u00e9teil  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annachiara","family":"Cagnin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience &amp; 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