{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:09:47Z","timestamp":1787166587921,"version":"build-2736575974"},"reference-count":99,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG GR 3285\/2\u20101"],"award-info":[{"award-number":["DFG GR 3285\/2\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2020,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Healthy aging is accompanied by changes in brain activation patterns in the motor system. In older subjects, unilateral hand movements typically rely on increased recruitment of ipsilateral frontoparietal areas. While the two central concepts of aging\u2010related brain activity changes, \u201cHemispheric Asymmetry Reduction in Older Adults\u201d (HAROLD), and \u201cPosterior to Anterior Shift in Aging\u201d (PASA), have initially been suggested in the context of cognitive tasks and were attributed to compensation, current knowledge regarding the functional significance of increased motor system activity remains scarce. We, therefore, used online interference transcranial magnetic stimulation in young and older subjects to investigate the role of key regions of the ipsilateral frontoparietal cortex, that is, (a) primary motor cortex (M1), (b) dorsal premotor cortex (dPMC), and (c) anterior intraparietal sulcus (IPS) in the control of hand movements of different motor demands. Our data suggest a change of the functional roles of ipsilateral brain areas in healthy age with a reduced relevance of ipsilateral M1 and a shift of importance toward dPMC for repetitive high\u2010frequency movements. These results support the notion that mechanisms conceptualized in the models of \u201cPASA\u201d and \u201cHAROLD\u201d also apply to the motor system.<\/jats:p>","DOI":"10.1002\/hbm.24829","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T03:05:04Z","timestamp":1571195104000},"page":"640-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Age affects the contribution of ipsilateral brain regions to movement kinematics"],"prefix":"10.1002","volume":"41","author":[{"given":"Caroline","family":"Tscherpel","sequence":"first","affiliation":[{"name":"Medical Faculty University of Cologne and Department of Neurology, University Hospital Cologne  Cologne Germany"},{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM\u20103) Research Centre J\u00fclich, J\u00fclich  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Hensel","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Cologne and Department of Neurology, University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Lemberg","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Cologne and Department of Neurology, University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Freytag","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Cologne and Department of Neurology, University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Michely","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Cologne and Department of Neurology, University Hospital Cologne  Cologne Germany"},{"name":"Wellcome Trust Centre for Neuroimaging, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas J.","family":"Volz","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Cologne and Department of Neurology, University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gereon R.","family":"Fink","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Cologne and Department of Neurology, University Hospital Cologne  Cologne Germany"},{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM\u20103) Research Centre J\u00fclich, J\u00fclich  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1656-720X","authenticated-orcid":false,"given":"Christian","family":"Grefkes","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Cologne and Department of Neurology, University Hospital Cologne  Cologne Germany"},{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM\u20103) Research Centre J\u00fclich, J\u00fclich  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061883"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00222895.2015.1056766"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-424X(09)70205-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.07.035"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.06.021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5642-09.2010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050838"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.5.1253"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-6-67"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00110.2014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1280"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-01-00391.1997"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.2.253"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1684-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410216"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00950.2002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80429-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.22.1.319"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00209"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.1.383"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1591-5"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3386-05.2006"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj152"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00241"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm155"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050648"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21024"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057765"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.06.033"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019243"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.06.712"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00539-3"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.249bz.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3256"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2005.00426.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21228"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.08.031"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/72.5.373"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs147"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.11.020"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01331.2006"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.01.003"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1263-05.2005"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3300-07.2008"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00822.2011"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052573"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(02)00417-0"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1309"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002219900224"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901880111"},{"key":"e_1_2_8_52_1","first-page":"97","article-title":"Mechanisms of selection and guidance of reaching movements in the parietal lobe","volume":"93","author":"Kalaska J. F.","year":"2003","journal-title":"Advances in Neurology"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8342027"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1158-06.2006"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(97)00008-0"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.08.010"},{"key":"e_1_2_8_57_1","first-page":"17","article-title":"Functional implications of age differences in motor system connectivity","volume":"4","author":"Langan J.","year":"2010","journal-title":"Frontiers in Systems Neuroscience"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.04.001"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0046-11.2011"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4564-05.2006"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02807.x"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.4.630"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.2.429"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.02.001"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.072843"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10848"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4993-13.2014"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.06.004"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13569"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn201"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05551.x"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05795.x"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0476"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780198523758.001.0001"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.023"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq140"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8721.2008.00570.x"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.05.021"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(97)80037-2"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0703-04.2004"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.08.016"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.02.001"},{"key":"e_1_2_8_83_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-0879-0","volume-title":"Neuromethods: Transcranial magnetic stimulation","author":"Rotenberg A.","year":"2014"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0511(00)00052-1"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.10.005"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.12.023"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2017.09.007"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-002-1292-5"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.01.039"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.01.016"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-007-1205-8"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00150-5"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00720.2004"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.07.024"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/35036239"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.01.024"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2006.04.003"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg071"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.04.017"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.1.141"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.24829","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T14:06:11Z","timestamp":1694009171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.24829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,16]]},"references-count":99,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2,15]]}},"alternative-id":["10.1002\/hbm.24829"],"URL":"https:\/\/doi.org\/10.1002\/hbm.24829","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,16]]},"assertion":[{"value":"2019-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}