{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:13:19Z","timestamp":1790766799107,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001208","name":"Heart Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001208","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high\u2010angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort (\n                    <jats:italic>n<\/jats:italic>\n                    =\u2009140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly\u2010connected \u201cstructural core\u201d of the ECN comprising three components: interhemispheric frontal connections, a fronto\u2010parietal subnetwork and fronto\u2010striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance (\n                    <jats:italic>p<\/jats:italic>\n                    =\u2009.003). Post\u2010hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour.\n                  <\/jats:p>","DOI":"10.1002\/hbm.24870","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T08:35:28Z","timestamp":1574670928000},"page":"1226-1236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Structural core of the executive control network: A high angular resolution diffusion MRI study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5956-501X","authenticated-orcid":false,"given":"Kai\u2010kai","family":"Shen","sequence":"first","affiliation":[{"name":"Australian eHealth Research Centre CSIRO  Floreat Western Australia Australia"},{"name":"Department of Biomedical Sciences Macquarie University  Sydney New South Wales Australia"},{"name":"Sydney Translational Imaging Laboratory Heart Research Institute, Charles Perkins Centre, University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Welton","sequence":"additional","affiliation":[{"name":"Sydney Translational Imaging Laboratory Heart Research Institute, Charles Perkins Centre, University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Lyon","sequence":"additional","affiliation":[{"name":"Sydney Translational Imaging Laboratory Heart Research Institute, Charles Perkins Centre, University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"McCorkindale","sequence":"additional","affiliation":[{"name":"Sydney Translational Imaging Laboratory Heart Research Institute, Charles Perkins Centre, University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg T.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Charles Perkins Centre and School of Medical Sciences, University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Burnham","sequence":"additional","affiliation":[{"name":"Australian eHealth Research Centre CSIRO  Floreat Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Fripp","sequence":"additional","affiliation":[{"name":"Australian eHealth Research Centre CSIRO  Floreat Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2712-157X","authenticated-orcid":false,"given":"Stuart M.","family":"Grieve","sequence":"additional","affiliation":[{"name":"Sydney Translational Imaging Laboratory Heart Research Institute, Charles Perkins Centre, University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Radiology Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00336-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.019"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1634"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2016.03.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000460"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0140-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715002767"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23429"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-009-0208-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601417103"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-301682"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw157"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"issue":"3","key":"e_1_2_8_15_1","first-page":"2303","article-title":"The disconnected brain and executive function decline in aging","volume":"27","author":"Fjell A. 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