{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:41:17Z","timestamp":1790538077482,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010803","name":"Department of Biotechnology, Government of West Bengal","doi-asserted-by":"publisher","award":["BT\/PR14315\/MED\/30\/474\/2010"],"award-info":[{"award-number":["BT\/PR14315\/MED\/30\/474\/2010"]}],"id":[{"id":"10.13039\/501100010803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["ICMR\/003\/304\/2013\/00694"],"award-info":[{"award-number":["ICMR\/003\/304\/2013\/00694"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["ECR\/2016\/000808"],"award-info":[{"award-number":["ECR\/2016\/000808"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Microstructural changes associated with degeneration of dopaminergic neurons of the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) have been studied using Diffusion Tensor Imaging (DTI). However, these studies show inconsistent results, mainly due to methodological variations in delineation of SNc. To mitigate this, our work aims to construct a probabilistic atlas of SNc based on a 3D Neuromelanin Sensitive MRI (NMS\u2010MRI) sequence and demonstrate its applicability to investigate microstructural changes on a large dataset of PD. Using manual segmentation and deformable registration we created a novel SNc atlas in the MNI space using NMS\u2010MRI sequences of 27 healthy controls (HC). We first quantitatively evaluated this atlas and then employed it to investigate the micro\u2010structural abnormalities in SNc using diffusion MRI from 133 patients with PD and 99 HCs. Our results demonstrated significant increase in diffusivity with no changes in anisotropy. In addition, we also observed an asymmetry of the diffusion metrics with a higher diffusivity and lower anisotropy in the left SNc than the right. Finally, a multivariate classifier based on SNc diffusion features could delineate patients with PD with an average accuracy of 71.7%. Overall, from this work we establish a normative baseline for the SNc region of interest using NMS\u2010MRI while the application on PD data emphasizes on the contribution of diffusivity measures rather than anisotropy of white matter in PD.<\/jats:p>","DOI":"10.1002\/hbm.24878","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T08:30:27Z","timestamp":1574929827000},"page":"1323-1333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Microstructural abnormalities of substantia nigra in Parkinson's disease: A neuromelanin sensitive MRI atlas based study"],"prefix":"10.1002","volume":"41","author":[{"given":"Apoorva","family":"Safai","sequence":"first","affiliation":[{"name":"Symbiosis Center for Medical Image Analysis, Symbiosis Institute of Technology Symbiosis International University  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences National Institute of Mental Health &amp; Neurosciences  Bangalore Karnataka India"},{"name":"Department of Neurology National Institute of Mental Health &amp; Neurosciences  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanay","family":"Chougule","sequence":"additional","affiliation":[{"name":"Symbiosis Center for Medical Image Analysis, Symbiosis Institute of Technology Symbiosis International University  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitender","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging &amp; Interventional Radiology National Institute of Mental Health &amp; Neurosciences  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod K.","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health &amp; Neurosciences  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4809-8559","authenticated-orcid":false,"given":"Madhura","family":"Ingalhalikar","sequence":"additional","affiliation":[{"name":"Symbiosis Center for Medical Image Analysis, Symbiosis Institute of Technology Symbiosis International University  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp257"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1595-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2018.2872852"},{"issue":"3","key":"e_1_2_8_5_1","first-page":"332","article-title":"T2\u2010weighted MRI in Parkinson's disease; substantia nigra pars compacta hypointensity correlates with the clinical scores","volume":"52","author":"Atasoy H. T.","year":"2004","journal-title":"Neurology India"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829e6fd2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26201"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.121525"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20076-y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23643"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200618"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.5.2283"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1556"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000194845.19462.7B"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"issue":"4","key":"e_1_2_8_20_1","first-page":"697","article-title":"Structural changes of the substantia nigra in Parkinson's disease as revealed by MR imaging","volume":"21","author":"Hutchinson M.","year":"2000","journal-title":"AJNR. American Journal of Neuroradiology"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00196"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.081"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2010.08.043"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1199-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.12.037"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2018.01.023"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.045"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23192"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26883"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-018-1891-3"},{"key":"e_1_2_8_31_1","first-page":"18","article-title":"Classification and regression by random Forest","volume":"2","author":"Liaw A.","year":"2002","journal-title":"R News"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26606"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.09.011"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350291"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.086"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1171-8"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.04.005"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.02.012"},{"issue":"10","key":"e_1_2_8_39_1","first-page":"1747","article-title":"The substantia nigra in Parkinson disease: Proton density\u2010weighted spin\u2010echo and fast short inversion time inversion\u2010recovery MR findings","volume":"23","author":"Oikawa H.","year":"2002","journal-title":"AJNR. American Journal of Neuroradiology"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.63"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq212"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.05.021"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.04.022"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13573"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530350033015"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12613"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-5915-2"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24574-4_28"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328315a637"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000227984.84927.a7"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26325"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.10.006"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23722"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2017.0506"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101748"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.11.1524"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20180037"},{"key":"e_1_2_8_59_1","first-page":"1","article-title":"Magnetic resonance imaging (MRI) in Parkinson's disease","volume":"3","author":"Tuite P. J.","year":"2013","journal-title":"Journal of Alzheimers Disease and Parkinsonism"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000340982.01727.6e"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.013"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.02.007"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23917"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26251"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.24878","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T04:56:54Z","timestamp":1693976214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.24878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,28]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/hbm.24878"],"URL":"https:\/\/doi.org\/10.1002\/hbm.24878","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/686154","asserted-by":"object"}]},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,28]]},"assertion":[{"value":"2019-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}