{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:42:35Z","timestamp":1784774555589,"version":"3.55.0"},"reference-count":118,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2020,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pharmacological modulation of functional connectivity in the brain may underlie therapeutic efficacy for several neurological and psychiatric disorders. Functional magnetic resonance imaging (fMRI) provides a noninvasive method of assessing this modulation, however, the indirect nature of the blood\u2010oxygen level dependent signal restricts the discrimination of neural from physiological contributions. Here we followed two approaches to assess the validity of fMRI functional connectivity in developing drug biomarkers, using simultaneous electroencephalography (EEG)\/fMRI in a placebo\u2010controlled, three\u2010way crossover design with ketamine and midazolam. First, we compared seven different preprocessing pipelines to determine their impact on the connectivity of common resting\u2010state networks. Independent components analysis (ICA)\u2010denoising resulted in stronger reductions in connectivity after ketamine, and weaker increases after midazolam, than pipelines employing physiological noise modelling or averaged signals from cerebrospinal fluid or white matter. This suggests that pipeline decisions should reflect a drug's unique noise structure, and if this is unknown then accepting possible signal loss when choosing extensive ICA denoising pipelines could engender more confidence in the remaining results. We then compared the temporal correlation structure of fMRI to that derived from two connectivity metrics of EEG, which provides a direct measure of neural activity. While electrophysiological estimates based on the power envelope were more closely aligned to BOLD signal connectivity than those based on phase consistency, no significant relationship between the change in electrophysiological and hemodynamic correlation structures was found, implying caution should be used when making cross\u2010modal comparisons of pharmacologically\u2010modulated functional connectivity.<\/jats:p>","DOI":"10.1002\/hbm.24889","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T09:07:15Z","timestamp":1575623235000},"page":"1472-1494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Modulation of simultaneously collected hemodynamic and electrophysiological functional connectivity by ketamine and midazolam"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3283-2691","authenticated-orcid":false,"given":"Anna","family":"Forsyth","sequence":"first","affiliation":[{"name":"School of Pharmacy, Faculty of Medical and Health Sciences The University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"McMillan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medical and Health Sciences The University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Auckland District Health Board  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Malpas","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Auckland District Health Board  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Auckland District Health Board  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Sleigh","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Faculty of Medical and Health Sciences The University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Dukart","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Medicine, Brain &amp; Behaviour (INM\u20107) Research Centre J\u00fclich  J\u00fclich Germany"},{"name":"Institute of Systems Neuroscience, Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Hipp","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, Roche Innovation Center Basel F. Hoffmann\u2010La Roche Ltd.  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh D.","family":"Muthukumaraswamy","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medical and Health Sciences The University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.45"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00260"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0599"},{"key":"e_1_2_7_5_1","unstructured":"Andersson J. L. R. Jenkinson M. &Smith S.(2010).Non\u2010linear registration aka spatial normalisation. FMRIB Technical Report No. TR07 JA2."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.07.022"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2004.10.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2015.00175"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2003.822821"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.048"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.099"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.11.059"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00114"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001275"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.070"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.054"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.09.018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150444"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.12.018"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.029"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.048"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1520613113"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.034"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.210"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.08.035"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.09.037"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2007.37"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00258"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.201665"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","DOI":"10.1093\/acprof:oso\/9780195372731.003.0006","article-title":"Removal of MRI artifacts from EEG recordings","volume":"2","author":"Eichele T.","year":"2010","journal-title":"In Simultaneous EEG and fMRI: Recording, Analysis and Application"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.09.038"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.9.851"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.03.031"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913008107"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101739"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-5064-8"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350312"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20446"},{"key":"e_1_2_7_41_1","article-title":"Using temporal ICA to selectively remove global noise while preserving global signal in functional MRI data","volume":"181","author":"Glasser M. F.","year":"2018","journal-title":"BioRxiv"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4361"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200007)44:1<162::AID-MRM23>3.0.CO;2-E"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200212200-00022"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328306f2c5"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20537"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.03.034"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-4022-y"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20889"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3101"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.03.049"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-010-0199-6"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2011.03.006"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2007.03.018"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-3951-9"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0810-09.2009"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.09.044"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.12.050"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2005.02.009"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1978.234.4.H371"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950030035004"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1999.11740995"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00286-6"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22914"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.042"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-10-03963.2003"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3985-11.2012"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00825"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700668104"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.05.051"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881118822263"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.1998.00323.x"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2004.834272"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.024"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.05.037"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.001"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.036"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0903-15.2015"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00115"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31826a0db3"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.04.029"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1177\/1550059419838938"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.19859"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/156869"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.006"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.048"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1720985115"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.09.038"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145700001814"},{"key":"e_1_2_7_92_1","first-page":"153","volume-title":"EEG \u2010 fMRI: Physiological basis, technique, and applications","author":"Ritter P.","year":"2010"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20160"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.11.046"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2007.05.017"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044799"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913110107"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.037"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3137"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80821-1"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24069"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.03.008"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.064"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.07.044"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.623056"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.055"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.03.011"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2008"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.005"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0187-16.2016"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00433"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1172"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139597"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.08.053"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1710"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.03.010"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.24889","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24889","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.24889","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.24889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:03:36Z","timestamp":1694045016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.24889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,6]]},"references-count":118,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,4,15]]}},"alternative-id":["10.1002\/hbm.24889"],"URL":"https:\/\/doi.org\/10.1002\/hbm.24889","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,6]]},"assertion":[{"value":"2019-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}