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However, the characteristics of local brain activity over time in GAD are poorly understood. This study aimed to investigate the abnormal time\u2010varying local brain activity of GAD by using the amplitude of low\u2010frequency fluctuation (ALFF) method combined with sliding\u2010window approach. Group comparison results showed that compared with healthy controls (HCs), patients with GAD exhibited increased dynamic ALFF (dALFF) variability in widespread regions, including the bilateral dorsomedial prefrontal cortex, hippocampus, thalamus, striatum; and left orbital frontal gyrus, inferior parietal lobule, temporal pole, inferior temporal gyrus, and fusiform gyrus. The abnormal dALFF could be used to distinguish between patients with GAD and HCs. Increased dALFF variability values in the striatum were positively correlated with GAD symptom severity. These findings suggest that GAD patients are associated with abnormal temporal variability of local brain activity in regions implicated in executive, emotional, and social function. This study provides insight into the brain dysfunction of GAD from the perspective of dynamic local brain activity, highlighting the important role of dALFF variability in understanding neurophysiological mechanisms and potentially informing the diagnosis of GAD.<\/jats:p>","DOI":"10.1002\/hbm.24902","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T02:41:46Z","timestamp":1576636906000},"page":"1667-1676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":146,"title":["Dynamic changes of amplitude of low\u2010frequency fluctuations in patients with generalized anxiety disorder"],"prefix":"10.1002","volume":"41","author":[{"given":"Qian","family":"Cui","sequence":"first","affiliation":[{"name":"School of Public Affairs and Administration University of Electronic Science and Technology of China  Chengdu 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