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Here, we measured neuromagnetic brain activity to investigate the neural timing of cortical areas needed for inhibitory control, while 14 healthy young adults performed an interleaved prosaccade (look at a peripheral visual stimulus) and antisaccade (look away from stimulus) task. Analysis of how neural activity relates to saccade reaction time (SRT) and occurrence of direction errors (look at stimulus on antisaccade trials) provides insight into inhibitory control. Neuromagnetic source activity was used to extract stimulus\u2010aligned and saccade\u2010aligned activity to examine temporal differences between prosaccade and antisaccade trials in brain regions associated with saccade control. For stimulus\u2010aligned antisaccade trials, a longer SRT was associated with delayed onset of neural activity within the ipsilateral parietal eye field (PEF) and bilateral frontal eye field (FEF). Saccade\u2010aligned activity demonstrated peak activation 10ms before saccade\u2010onset within the contralateral PEF for prosaccade trials and within the bilateral FEF for antisaccade trials. In addition, failure to inhibit prosaccades on anti\u2010saccade trials was associated with increased activity prior to saccade onset within the FEF contralateral to the peripheral stimulus. This work on dynamic activity adds to our knowledge that direction errors were due, at least in part, to a failure to inhibit automatic prosaccades. These findings provide novel evidence in humans regarding the temporal dynamics within oculomotor areas needed for saccade programming and the role frontal brain regions have on top\u2010down inhibitory control.<\/jats:p>","DOI":"10.1002\/hbm.24922","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T03:53:01Z","timestamp":1578541981000},"page":"1934-1949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mapping neural dynamics underlying saccade preparation and execution and their relation to reaction time and direction errors"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8688-1571","authenticated-orcid":false,"given":"Sonya","family":"Bells","sequence":"first","affiliation":[{"name":"Program in Neurosciences and Mental Health, The Hospital for Sick Children Research Institute  Toronto Ontario 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