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We aim to investigate the relationship between early\u2010onset AD (EOAD) and FTLD structural alterations and CSF biomarker levels. We included 138 subjects (64 EOAD, 26 FTLD, and 48 controls), all of them with a 3T MRI brain scan and CSF biomarkers available (the 42 amino acid\u2010long form of the amyloid\u2010beta protein [A\u03b242], total\u2010tau protein [T\u2010tau], neurofilament light chain [NfL], neurogranin [Ng], and 14\u20103\u20103 levels). We used FreeSurfer and FSL to obtain cortical thickness (CTh) and fraction anisotropy (FA) maps. We studied group differences in CTh and FA and described the \u201cAD signature\u201d and \u201cFTLD signature.\u201d We tested multiple regression models to find which CSF\u2010biomarkers better explained each disease neuroimaging signature. CTh and FA maps corresponding to the AD and FTLD signatures were in accordance with previous literature. Multiple regression analyses showed that the biomarkers that better explained CTh values within the AD signature were A\u03b2 and 14\u20103\u20103; whereas NfL and 14\u20103\u20103 levels explained CTh values within the FTLD signature. Similarly, NfL levels explained FA values in the FTLD signature. Ng levels were not predictive in any of the models. Biochemical markers contribute differently to structural (CTh and FA) changes typical of AD and FTLD.<\/jats:p>","DOI":"10.1002\/hbm.24925","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T16:30:44Z","timestamp":1579192244000},"page":"2004-2013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Contribution of CSF biomarkers to early\u2010onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3404-2765","authenticated-orcid":false,"given":"Neus","family":"Falg\u00e0s","sequence":"first","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Cl\u00ednic Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Fundaci\u00f3 Cl\u00ednic per a la Recerca Biom\u00e8dica, University of Barcelona  Barcelona 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