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Nonetheless, longitudinal trajectory of A\u03b2\u2010associated hippocampal subfield atrophy prior to dementia remains unclear. We hypothesized that elevated A\u03b2 correlated with longitudinal subfield atrophy selectively in no cognitive impairment (NCI), spreading to other subfields in mild cognitive impairment (MCI). We analyzed data from two independent longitudinal cohorts of nondemented elderly, including global PET\u2010A\u03b2 in AD\u2010vulnerable cortical regions and longitudinal subfield volumes quantified with a novel auto\u2010segmentation method (FreeSurfer v.6.0). Moreover, we investigated associations of A\u03b2\u2010related progressive subfield atrophy with memory decline. Across both datasets, we found a converging pattern that higher A\u03b2 correlated with faster CA1 volume decline in NCI. This pattern spread to other hippocampal subfields in MCI group, correlating with memory decline. 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