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In this study, the role of the affective\u2010cognitive network was explored in two phenotypes of FD: fixed (FixFD) and mobile dystonia (MobFD). We hypothesized that each of these phenotypes would show peculiar functional connectivity (FC) alterations in line with their divergent disease clinical expressions. Resting state fMRI (RS\u2010fMRI) was obtained in 40 FD patients (12 FixFD; 28 MobFD) and 43 controls (14 young FixFD\u2010age\u2010matched [yHC]; 29 old MobFD\u2010age\u2010matched [oHC]). FC of brain regions of interest, known to be involved in affective\u2010cognitive processes, and independent component analysis of RS\u2010fMRI data to explore brain networks were employed. Compared to HC, all FD patients showed reduced FC between the majority of affective\u2010cognitive seeds of interest and the fronto\u2010subcortical and limbic circuits; enhanced FC between the right affective\u2010cognitive part of the cerebellum and the bilateral associative parietal cortex; enhanced FC of the bilateral amygdala with the subcortical and posterior cortical brain regions; and altered FC between the left medial dorsal nucleus and the sensorimotor and associative brain regions (enhanced in MobFD and reduced in FixFD). Compared with yHC and MobFD patients, FixFD patients had an extensive pattern of reduced FC within the cerebellar network, and between the majority of affective\u2010cognitive seeds of interest and the sensorimotor and high\u2010order function (\u201ccognitive\u201d) areas with a unique involvement of dorsal anterior cingulate cortex connectivity. Brain FC within the affective\u2010cognitive network is altered in FD and presented specific features associated with each FD phenotype, suggesting an interaction between brain connectivity and clinical expression of the disease.<\/jats:p>","DOI":"10.1002\/hbm.24997","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T15:16:42Z","timestamp":1585927002000},"page":"3059-3076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Breakdown of the affective\u2010cognitive network in functional dystonia"],"prefix":"10.1002","volume":"41","author":[{"given":"Elisa","family":"Canu","sequence":"first","affiliation":[{"name":"Neuroimaging Research Unit Institute of Experimental Neurology  Division of Neuroscience, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Agosta","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit Institute of Experimental Neurology  Division of Neuroscience, Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Tomic","sequence":"additional","affiliation":[{"name":"Clinic of Neurology, Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Sarasso","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit Institute of Experimental Neurology  Division of Neuroscience, Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Petrovic","sequence":"additional","affiliation":[{"name":"Clinic of Neurology, Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Piramide","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit Institute of Experimental Neurology  Division of Neuroscience, Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Svetel","sequence":"additional","affiliation":[{"name":"Clinic of Neurology, Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Inuggi","sequence":"additional","affiliation":[{"name":"Unit of Robotics, Brain and Cognitive Sciences Istituto Italiano di Tecnologia  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasa","family":"D. 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