{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:27Z","timestamp":1786977807250,"version":"build-2736575974"},"reference-count":98,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2020,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ventromedial regions of the frontal lobe (vmFL) are thought to play a key role in decision\u2010making and emotional regulation. However, aspects of this area's functional organization, including the presence of a multiple subregions, their functional and anatomical connectivity, and the cross\u2010species homologies of these subregions with those of other species, remain poorly understood. To address this uncertainty, we employed a two\u2010stage parcellation of the region to identify six distinct structures within the region on the basis of data\u2010driven classification of functional connectivity patterns obtained using the meta\u2010analytic connectivity modeling (MACM) approach. From anterior to posterior, the derived subregions included two lateralized posterior regions, an intermediate posterior region, a dorsal and ventral central region, and a single anterior region. The regions were characterized further by functional connectivity derived using resting\u2010state fMRI and functional decoding using the Brain Map database. In general, the regions could be differentiated on the basis of different patterns of functional connectivity with canonical \u201cdefault mode network\u201d regions and\/or subcortical regions such as the striatum. Together, the findings suggest the presence of functionally distinct neural structures within vmFL, consistent with data from experimental animals as well prior demonstrations of anatomical differences within the region. Detailed correspondence with the anterior cingulate, medial orbitofrontal cortex, and rostroventral prefrontal cortex, as well as specific animal homologs are discussed. The findings may suggest future directions for resolving potential functional and structural correspondence of subregions within the frontal lobe across behavioral contexts, and across mammalian species.<\/jats:p>","DOI":"10.1002\/hbm.25014","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T04:53:45Z","timestamp":1587444825000},"page":"3266-3283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Functional differentiation in the human ventromedial frontal lobe: A data\u2010driven parcellation"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9780-095X","authenticated-orcid":false,"given":"Henry W.","family":"Chase","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony A.","family":"Grace","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Department of Neuroscience and Psychology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Fox","sequence":"additional","affiliation":[{"name":"Research Imaging Institute University of Texas Health Science Center  San Antonio Texas USA"},{"name":"Department of Radiology University of Texas Health Science Center  San Antonio Texas USA"},{"name":"Department of Psychiatry University of Texas Health Science Center  San Antonio Texas USA"},{"name":"Research and Development Service South Texas Veterans Health Care System  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon B.","family":"Eickhoff","sequence":"additional","affiliation":[{"name":"Institute of Systems Neuroscience, Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Institute of Neuroscience and Medicine, Brain &amp; Behaviour (INM\u20107) Research Centre J\u00fclich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1399"},{"issue":"5","key":"e_1_2_7_3_1","first-page":"523","article-title":"Afferent projections of the infralimbic cortex (area 25) in rats: A WGA\u2010HRP study","volume":"71","author":"Azuma M.","year":"1996","journal-title":"Kaibogaku Zasshi"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507062103"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2016.07.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902860306"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90132-Y"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3950"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.3.295"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-11-04320.2000"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.052"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.06.038"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.11.009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22138"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-24-09917.2001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.032"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.069"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.01.013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(20000619)422:1<35::AID-CNE3>3.0.CO;2-E"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00348"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-25-08771.2003"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs256"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn066"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nst106"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.06.041"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4438"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-008-0189-x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.017"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.05.021"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.02.018"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20718"},{"key":"e_1_2_7_33_1","article-title":"Common default mode network dysfunction across psychopathologies: A neuroimaging meta\u2010analysis of the n\u2010back working memory paradigm","author":"Farruggia M. C.","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06229.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.039"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn789"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206608109"},{"issue":"3","key":"e_1_2_7_38_1","first-page":"592","article-title":"Prefrontal cortex dysfunction increases susceptibility to schizophrenia\u2010like changes induced by adolescent stress exposure","volume":"43","author":"Gomes F. V.","year":"2017","journal-title":"Schizophrenia Bulletin"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00380-6"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.05.012"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.11.006"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.10.030"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-007-0150-4"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601485113"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2019.12.004"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz079"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv215"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0257-12.2012"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912838107"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2827-16.2016"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/13.4.400"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-349"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.12.002"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09108"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22645"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.66.082602.092845"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12654"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu164"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2016.01.005"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.02.014"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3337"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmva.2006.11.013"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410767112"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0470-8"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10609"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.04.053"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2449-13.2013"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2419-07.2007"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09278.x"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2015.08.002"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.07.072"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1081-0"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20126"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-09-05437.1994"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902420104"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-01-00324.2002"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2012.01.005"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.3758\/CABN.8.4.485"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.09.036"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0091-11.2011"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317695111"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21577"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116366"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1378-2"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902900205"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1037\/rev0000118"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91677-S"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1131"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0005-09.2009"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037454"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10279"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14518-3"},{"key":"e_1_2_7_96_1","unstructured":"Walter B. Blecker C. Kirsch P. Sammer G. Schienle A. Stark R. &Vaitl D. (2003 June 19\u201322).MARINA: An Easy to Use Tool for the Creation of MAsks for Region of INterest Analyses. Paper presented at the 9th International Conference on Functional Mapping of the Human Brain New York NY."},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.07.029"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.08.008"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2011.03.004"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.25014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.25014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T18:44:45Z","timestamp":1693939485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.25014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,21]]},"references-count":98,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,8,15]]}},"alternative-id":["10.1002\/hbm.25014"],"URL":"https:\/\/doi.org\/10.1002\/hbm.25014","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,21]]},"assertion":[{"value":"2019-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}