{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:29:49Z","timestamp":1780464589885,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Irish Government, the Health Research Board"},{"name":"Irish Life PLc"},{"name":"The Altantic Philantrophies"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2020,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The thalamus is a central hub of the autonomic network and thalamic volume has been associated with high\u2010risk phenotypes for sudden cardiac death. Heart rate response to physiological stressors (e.g., standing) and the associated recovery patterns provide reliable indicators of both autonomic function and cardiovascular risk. Here we examine if thalamic volume may be a risk marker for impaired heart rate recovery in response to orthostatic challenge. The Irish Longitudinal Study on Aging involves a nationally representative sample of older individuals aged \u226550\u2009years. Multimodal brain magnetic resonance imaging and orthostatic heart rate recovery were available for a cross\u2010sectional sample of 430 participants. Multivariable regression and linear mixed\u2010effects models were adjusted for head size, age, sex, education, body mass index, blood pressure, history of cardiovascular diseases and events, cardiovascular medication, diabetes mellitus, smoking, alcohol intake, timed up\u2010and\u2010go (a measure of physical frailty), physical exercise and depression. Smaller thalamic volume was associated with slower heart rate recovery (\u22121.4 bpm per 1 cm<jats:sup>3<\/jats:sup> thalamic volume, 95% CI \u22122.01 to \u22120.82; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). In multivariable analysis, participants with smaller thalamic volumes had a mean heart rate recovery \u22122.7 bpm slower than participants with larger thalamic volumes (95% CI \u22123.89 to \u22121.61; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Covariates associated with smaller thalamic volume included age, history of diabetes, and heavy alcohol consumption. Thalamic volume may be an indicator of the structural integrity of the central autonomic network. It may be a clinical biomarker for stratification of individuals at risk of autonomic dysfunction, cardiovascular events, and sudden cardiac death.<\/jats:p>","DOI":"10.1002\/hbm.25022","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T19:06:38Z","timestamp":1588273598000},"page":"3370-3378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impaired orthostatic heart rate recovery is associated with smaller thalamic volume: Results from The Irish Longitudinal Study on Aging (<scp>TILDA<\/scp>)"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-8357","authenticated-orcid":false,"given":"C\u00e9line","family":"De Looze","sequence":"first","affiliation":[{"name":"The Irish Longitudinal Study on Ageing, Trinity College, University of Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilby","family":"Williamson","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing, Trinity College, University of Dublin  Dublin Ireland"},{"name":"Department of Physiology Trinity College Dublin  Dublin Ireland"},{"name":"Global Brain Health Institute, Trinity College Dublin  Dublin Ireland"},{"name":"Oxford Cardiovascular Clinical Research Facility Division of Cardiovascular Medicine, Radcliffe Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Hirst","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing, Trinity College, University of Dublin  Dublin Ireland"},{"name":"School of Psychology and Institute of Neuroscience, Trinity College Dublin  Dublin 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