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MRI has been fundamental in advancing our understanding of brain processes in the epilepsies. Smaller\u2010scale studies have identified many interesting imaging phenomena, with implications both for understanding pathophysiology and improving clinical care. Through the infrastructure and concepts now well\u2010established by the ENIGMA Consortium, ENIGMA\u2010Epilepsy was established to strengthen epilepsy neuroscience by greatly increasing sample sizes, leveraging ideas and methods established in other ENIGMA projects, and generating a body of collaborating scientists and clinicians to drive forward robust research. Here we review published, current, and future projects, that include structural MRI, diffusion tensor imaging (DTI), and resting state functional MRI (rsfMRI), and that employ advanced methods including structural covariance, and event\u2010based modeling analysis. We explore age of onset\u2010 and duration\u2010related features, as well as phenomena\u2010specific work focusing on particular epilepsy syndromes or phenotypes, multimodal analyses focused on understanding the biology of disease progression, and deep learning approaches. We encourage groups who may be interested in participating to make contact to further grow and develop ENIGMA\u2010Epilepsy.<\/jats:p>","DOI":"10.1002\/hbm.25037","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T04:44:35Z","timestamp":1590727475000},"page":"113-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["The\n                    <scp>ENIGMA\u2010Epilepsy<\/scp>\n                    working group: Mapping disease from large data sets"],"prefix":"10.1002","volume":"43","author":[{"given":"Sanjay M.","family":"Sisodiya","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology  London UK"},{"name":"Chalfont Centre for Epilepsy  Bucks UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Whelan","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Therapeutics The Royal College of Surgeons in Ireland  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-8726","authenticated-orcid":false,"given":"Sean N.","family":"Hatton","sequence":"additional","affiliation":[{"name":"Center for Multimodal Imaging and Genetics University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoa","family":"Huynh","sequence":"additional","affiliation":[{"name":"Center for Multimodal Imaging and Genetics University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9265-2393","authenticated-orcid":false,"given":"Andre","family":"Altmann","sequence":"additional","affiliation":[{"name":"Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering University College London  London 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8827-7324","authenticated-orcid":false,"given":"Angelo","family":"Labate","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Department of Medical and Surgical Sciences University \u201cMagna Gr\u00e6cia\" of Catanzaro  Catanzaro Italy"},{"name":"Institute of Neurology University \u201cMagna Gr\u00e6cia\" of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7384-3074","authenticated-orcid":false,"given":"Antonio","family":"Gambardella","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Department of Medical and Surgical Sciences University \u201cMagna Gr\u00e6cia\" of Catanzaro  Catanzaro Italy"},{"name":"Institute of Neurology University \u201cMagna Gr\u00e6cia\" of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Ives\u2010Deliperi","sequence":"additional","affiliation":[{"name":"Neuroscience Institute University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-539X","authenticated-orcid":false,"given":"Stefano","family":"Meletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Neurology Unit OCB Hospital, AOU Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent C.","family":"Munsell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of North Carolina  Chapel Hill North Carolina USA"},{"name":"Department of Computer Science University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Bonilha","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Tondelli","sequence":"additional","affiliation":[{"name":"Neurology Unit OCB Hospital, AOU Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8441-1485","authenticated-orcid":false,"given":"Michael","family":"Rebsamen","sequence":"additional","affiliation":[{"name":"Support Center for Advanced Neuroimaging University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern  Bern 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Sciences The Royal College of Surgeons in Ireland  Dublin Ireland"},{"name":"FutureNeuro SFI Research Centre  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9336-9568","authenticated-orcid":false,"given":"Fernando","family":"Cendes","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neuroimaging Laboratory University of Campinas \u2013 UNICAMP  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Concha","sequence":"additional","affiliation":[{"name":"Instituto de Neurobiolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico  Quer\u00e9taro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M.","family":"Desmond","sequence":"additional","affiliation":[{"name":"Department of Radiology Royal Melbourne Hospital, University of Melbourne  Melbourne Victoria 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