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Worse performance in one domain is associated with worse performance in the other domains. Commonality analysis (CA) is a method of variance partitioning in multiple regression, used to separate the specific and common influence of collinear predictors. We apply, for the first time, CA to the functional connectome to investigate the unique and common neural connectivity underlying the interface of the symptom domains in 74 non\u2010demented PD subjects. Edges were modeled as a function of global motor, cognitive, and neuropsychiatric scores. CA was performed, yielding measures of the unique and common contribution of the symptom domains. Bootstrap confidence intervals were used to determine the precision of the estimates and to directly compare each commonality coefficient. The overall model identified a network with the caudate nucleus as a hub. Neuropsychiatric impairment accounted for connectivity in the caudate\u2010dorsal anterior cingulate and caudate\u2010right dorsolateral prefrontal\u2010right inferior parietal circuits, while caudate\u2010medial prefrontal connectivity reflected a unique effect of both neuropsychiatric and cognitive impairment. Caudate\u2010precuneus connectivity was explained by both unique and shared influence of neuropsychiatric and cognitive symptoms. Lastly, posterior cortical connectivity reflected an interplay of the unique and common effects of each symptom domain. We show that CA can determine the amount of variance in the connectome that is unique and shared amongst motor, neuropsychiatric, and cognitive symptoms in PD, thereby improving our ability to interpret the data while gaining novel insight into networks at the interface of these symptom domains.<\/jats:p>","DOI":"10.1002\/hbm.25084","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T03:48:22Z","timestamp":1590983302000},"page":"3749-3764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Common and unique connectivity at the interface of motor, neuropsychiatric, and cognitive symptoms in Parkinson's disease: A commonality analysis"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8960-0640","authenticated-orcid":false,"given":"Stefan","family":"Lang","sequence":"first","affiliation":[{"name":"Cumming School of Medicine University of Calgary 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