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One possibility is that this is mediated by age\u2010related impairments in the recruitment of the left intraparietal sulcus (Left IPS), which has been shown to mediate the suppression of salient distractors in healthy, young participants. Alternatively, this effect may be due to a shift in engagement from proactive control to reactive control, possibly to compensate for age\u2010related impairments in proactive control. Another possibility is that this is due to changes in the functional specificity of brain regions that mediate salience suppression, expressed in changes in spontaneous connectivity of these regions. We assessed these possibilities by having participants engage in a proactive distractor suppression task while in an fMRI scanner. Although we did not find any age\u2010related differences in behavior, the young (<jats:italic>N<\/jats:italic>\u2009=\u200915) and older (<jats:italic>N<\/jats:italic>\u2009=\u200915) cohorts engaged qualitatively distinctive brain networks to complete the task. Younger participants engaged the predicted proactive control network, including the Left IPS. On the other hand, older participants simultaneously engaged both a proactive and a reactive network, but this was not a consequence of reduced network specificity as resting state functional connectivity was largely comparable in both age groups. Furthermore, improved behavioral performance for older adults was associated with increased resting state functional connectivity between these two networks. Overall, the results of this study suggest that age\u2010related differences in the recruitment of a left lateralized ventral fronto\u2010parietal network likely reflect the specific recruitment of reactive control mechanisms for distractor inhibition.<\/jats:p>","DOI":"10.1002\/hbm.25097","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T16:43:24Z","timestamp":1592930604000},"page":"3938-3955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The same, but different: Preserved distractor suppression in old age is implemented through an <scp>age\u2010specific<\/scp> reactive ventral <scp>fronto\u2010parietal<\/scp> network"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9271-2464","authenticated-orcid":false,"given":"Brandon K.","family":"Ashinoff","sequence":"first","affiliation":[{"name":"Centre for Human Brain Health (CHBH), School of Psychology University of Birmingham  Edgbaston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-1488","authenticated-orcid":false,"given":"Stephen D.","family":"Mayhew","sequence":"additional","affiliation":[{"name":"Centre for Human Brain Health (CHBH), School of Psychology University of Birmingham  Edgbaston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-1026","authenticated-orcid":false,"given":"Carmel","family":"Mevorach","sequence":"additional","affiliation":[{"name":"Centre for Human Brain Health (CHBH), School of Psychology University of Birmingham  Edgbaston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1016\/j.neuron.2007.10.038"},{"unstructured":"Ashinoff B. 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