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Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA\u2010Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMA\u2010Anxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA\u2010Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders.<\/jats:p>","DOI":"10.1002\/hbm.25100","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T07:43:38Z","timestamp":1593762218000},"page":"83-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["<scp>ENIGMA\u2010anxiety<\/scp>\n                    working group: Rationale for and organization of\n                    <scp>large\u2010scale<\/scp>\n                    neuroimaging studies of anxiety disorders"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8982-1670","authenticated-orcid":false,"given":"Janna Marie","family":"Bas\u2010Hoogendam","sequence":"first","affiliation":[{"name":"Department of Developmental and Educational Psychology Leiden University, Institute of Psychology Leiden The Netherlands"},{"name":"Department of Psychiatry Leiden University Medical Center Leiden The Netherlands"},{"name":"Leiden Institute for Brain and Cognition Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nynke A.","family":"Groenewold","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Mental Health University of Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moji","family":"Aghajani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Amsterdam UMC \/ VUMC Amsterdam The Netherlands"},{"name":"Department of Research &amp; Innovation GGZ inGeest Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle F.","family":"Freitag","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, Emotion and Development Branch Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Harrewijn","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, Emotion and Development Branch Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Hilbert","sequence":"additional","affiliation":[{"name":"Department of Psychology Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Jahanshad","sequence":"additional","affiliation":[{"name":"University of Southern California Keck School of Medicine Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0046-4070","authenticated-orcid":false,"given":"Sophia I.","family":"Thomopoulos","sequence":"additional","affiliation":[{"name":"University of Southern California Keck School of Medicine Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"University of Southern California Keck School of Medicine Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick J.","family":"Veltman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Amsterdam UMC \/ VUMC Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-9781","authenticated-orcid":false,"given":"Anderson M.","family":"Winkler","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, Emotion and Development Branch Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Lueken","sequence":"additional","affiliation":[{"name":"Department of Psychology Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Pine","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, Emotion and Development Branch Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nic J. 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