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Concurrently, it has been suggested that the brain's intrinsic resting\u2010state (rs) activity has a preliminary influence on processing of agency cues. Here, we investigated the relation between performance in an agency attribution task and functional interactions among brain regions as derived by network analysis of rs functional magnetic resonance imaging. The action\u2010effect delay was adaptively increased (range 90\u20131,620\u2009ms) and behavioral measures correlated to indices of cognitive processes and appraised self\u2010concepts. They were then regressed on local metrics of rs brain functional connectivity as to isolate the core areas enabling self\u2010agency. Across subjects, the time window for self\u2010agency was 90\u2013625\u2009ms, while the action\u2010effect integration was impacted by self\u2010evaluated personality traits. Neurally, the brain intrinsic organization sustaining consistency in self\u2010agency attribution was characterized by high connectiveness in the secondary visual cortex, and regional segregation in the primary somatosensory area. Decreased connectiveness in the secondary visual area, regional segregation in the superior parietal lobule, and information control within a primary visual cortex\u2010frontal eye fields network sustained self\u2010agency over long\u2010delayed effects. We thus demonstrate that self\u2010agency is grounded on the intrinsic mode of brain function designed to organize information for visuomotor integration. Our observation is relevant for current models of psychopathology in clinical conditions in which both rs activity and sense of agency are altered.<\/jats:p>","DOI":"10.1002\/hbm.25107","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T10:27:58Z","timestamp":1594808878000},"page":"4024-4040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sense of external agency is sustained by multisensory functional integration in the somatosensory cortex"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9546-7038","authenticated-orcid":false,"given":"Federica","family":"Piras","sequence":"first","affiliation":[{"name":"Department of Clinical and Behavioral Neurology, Neuropsychiatry Laboratory IRCCS Santa Lucia Foundation  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Vecchio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Behavioral Neurology, Neuropsychiatry Laboratory IRCCS Santa Lucia Foundation  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4095-7806","authenticated-orcid":false,"given":"Valentina","family":"Ciullo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Behavioral Neurology, Neuropsychiatry Laboratory IRCCS Santa Lucia Foundation  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9154-1758","authenticated-orcid":false,"given":"Tommaso","family":"Gili","sequence":"additional","affiliation":[{"name":"Networks Unit, IMT School for Advanced Studies  Lucca Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6317-8549","authenticated-orcid":false,"given":"Nerisa","family":"Banaj","sequence":"additional","affiliation":[{"name":"Department of Clinical and Behavioral Neurology, Neuropsychiatry Laboratory IRCCS Santa Lucia Foundation  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-5494","authenticated-orcid":false,"given":"Fabrizio","family":"Piras","sequence":"additional","affiliation":[{"name":"Department of Clinical and Behavioral Neurology, Neuropsychiatry Laboratory IRCCS Santa Lucia Foundation  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7432-4249","authenticated-orcid":false,"given":"Gianfranco","family":"Spalletta","sequence":"additional","affiliation":[{"name":"Department of Clinical and Behavioral Neurology, Neuropsychiatry Laboratory IRCCS Santa Lucia Foundation  Rome Italy"},{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17470919.2015.1072582"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507062103"},{"key":"e_1_2_10_5_1","volume-title":"Network science","author":"Barab\u00e1si A.\u2010L.","year":"2016"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1059712309343819"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-88-470-1587-6_9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2307\/2286476"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.048"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200107030-00023"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(02)01907-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1417.015"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37912-w"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","unstructured":"Caldarelli G.(2010).Scale\u2010free networks: Complex webs in nature and technology. 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