{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:08:01Z","timestamp":1791252481909,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EW1711A & B"],"award-info":[{"award-number":["01EW1711A & B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005191","name":"Craig H. Neilsen Foundation","doi-asserted-by":"publisher","award":["INSPIRED"],"award-info":[{"award-number":["INSPIRED"]}],"id":[{"id":"10.13039\/100005191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["681094"],"award-info":[{"award-number":["681094"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001708","name":"International Foundation for Research in Paraplegia","doi-asserted-by":"publisher","award":["IRP\u2010158"],"award-info":[{"award-number":["IRP\u2010158"]}],"id":[{"id":"10.13039\/501100001708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000334","name":"International Spinal Research Trust","doi-asserted-by":"publisher","award":["INSPIRED"],"award-info":[{"award-number":["INSPIRED"]}],"id":[{"id":"10.13039\/501100000334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000381","name":"Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["77\/2017"],"award-info":[{"award-number":["77\/2017"]}],"id":[{"id":"10.13039\/501100000381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000381","name":"Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["892\/08"],"award-info":[{"award-number":["892\/08"]}],"id":[{"id":"10.13039\/501100000381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["181362"],"award-info":[{"award-number":["181362"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["616905"],"award-info":[{"award-number":["616905"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["NT 2014\u20106193"],"award-info":[{"award-number":["NT 2014\u20106193"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008191","name":"Wings for Life","doi-asserted-by":"publisher","award":["WFL\u2010CH\u2010007\/14"],"award-info":[{"award-number":["WFL\u2010CH\u2010007\/14"]}],"id":[{"id":"10.13039\/100008191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2020,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multicenter clinical and quantitative magnetic resonance imaging (qMRI) studies require a high degree of reproducibility across different sites and scanner manufacturers, as well as time points. We therefore implemented a multiparameter mapping (MPM) protocol based on vendor's product sequences and demonstrate its repeatability and reproducibility for whole\u2010brain coverage. Within ~20\u2009min, four MPM metrics (magnetization transfer saturation [MT], proton density [PD], longitudinal [R1], and effective transverse [R2*] relaxation rates) were measured using an optimized 1\u2009mm isotropic resolution protocol on six 3\u2009T MRI scanners from two different vendors. The same five healthy participants underwent two scanning sessions, on the same scanner, at each site. MPM metrics were calculated using the hMRI\u2010toolbox. To account for different MT pulses used by each vendor, we linearly scaled the MT values to harmonize them across vendors. To determine longitudinal repeatability and inter\u2010site comparability, the intra\u2010site (i.e., scan\u2010rescan experiment) coefficient of variation (CoV), inter\u2010site CoV, and bias across sites were estimated. For MT, R1, and PD, the intra\u2010 and inter\u2010site CoV was between 4 and 10% across sites and scan time points for intracranial gray and white matter. A higher intra\u2010site CoV (16%) was observed in R2* maps. The inter\u2010site bias was below 5% for all parameters. In conclusion, the MPM protocol yielded reliable quantitative maps at high resolution with a short acquisition time. The high reproducibility of MPM metrics across sites and scan time points combined with its tissue microstructure sensitivity facilitates longitudinal multicenter imaging studies targeting microstructural changes, for example, as a quantitative MRI biomarker for interventional clinical trials.<\/jats:p>","DOI":"10.1002\/hbm.25122","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T09:34:36Z","timestamp":1594200876000},"page":"4232-4247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Multiparameter mapping of relaxation (<scp>R1<\/scp>, <scp>R2<\/scp>*), proton density and magnetization transfer saturation at <scp>3 T<\/scp>: A multicenter dual\u2010vendor reproducibility and repeatability study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9871-4073","authenticated-orcid":false,"given":"Tobias","family":"Leutritz","sequence":"first","affiliation":[{"name":"Department of Neurophysics Max Planck Institute for Human Cognitive and Brain Sciences  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9253-5680","authenticated-orcid":false,"given":"Maryam","family":"Seif","sequence":"additional","affiliation":[{"name":"Department of Neurophysics Max Planck Institute for Human Cognitive and Brain Sciences  Leipzig Germany"},{"name":"Spinal Cord Injury Center University Hospital Balgrist, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1371-5123","authenticated-orcid":false,"given":"Gunther","family":"Helms","sequence":"additional","affiliation":[{"name":"Medical Radiation Physics, Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0197-702X","authenticated-orcid":false,"given":"Rebecca S","family":"Samson","sequence":"additional","affiliation":[{"name":"NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation UCL Queen Square Institute of Neurology, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Curt","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center University Hospital Balgrist, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4851-2246","authenticated-orcid":false,"given":"Patrick","family":"Freund","sequence":"additional","affiliation":[{"name":"Department of Neurophysics Max Planck Institute for Human Cognitive and Brain Sciences  Leipzig Germany"},{"name":"Spinal Cord Injury Center University Hospital Balgrist, University of Zurich  Zurich Switzerland"},{"name":"Wellcome Centre for Human Neuroimaging UCL Queen Square Institute of Neurology, University College London  London UK"},{"name":"Department of Brain Repair &amp; Rehabilitation UCL Queen Square Institute of Neurology, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5239-1881","authenticated-orcid":false,"given":"Nikolaus","family":"Weiskopf","sequence":"additional","affiliation":[{"name":"Department of Neurophysics Max Planck Institute for Human Cognitive and Brain Sciences  Leipzig Germany"},{"name":"Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth Sciences Leipzig University  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.034"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.018"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26979"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21971"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25692"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.02.008"},{"key":"e_1_2_11_9_1","volume-title":"Quantitative MRI of the brain: Principles of physical measurement","author":"Cercignani M.","year":"2018"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1593\/tlo.13811"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22423"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/55\/15\/003"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.11.052"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.02.055"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23858"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2007.00132.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07895.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30138-3"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70146-7"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24508"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116364"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21756"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28852-6"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21542"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21732"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22849"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10266"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.053"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2015.02.013"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968318776371"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27421"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22421"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0561-8"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28206"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26058"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21122"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.08.026"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25135"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.029"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27442"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470869526.ch4"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32832d92de"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00254"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00278"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.10.023"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000222"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00095"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24599"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21120"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22394"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005258"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.25122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.25122","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T09:36:32Z","timestamp":1693906592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.25122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,8]]},"references-count":51,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2020,10,15]]}},"alternative-id":["10.1002\/hbm.25122"],"URL":"https:\/\/doi.org\/10.1002\/hbm.25122","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,8]]},"assertion":[{"value":"2019-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}