{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:42:59Z","timestamp":1786977779674,"version":"build-2736575974"},"reference-count":61,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771914"],"award-info":[{"award-number":["81771914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY19H180003"],"award-info":[{"award-number":["LY19H180003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2020,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Deficits in information processing speed (IPS) are among the earliest and most prominent cognitive manifestations in mild traumatic brain injury (mTBI). We investigated the impact of white matter fiber location on IPS outcome in an individual basis assessment. A total of 112 acute mild TBI with all CT negative underwent brain DTI and blood sampling for inflammation cytokines within 7\u2009days postinjury and 72 age\u2010 and sex matched healthy controls with same assessments were enrolled. IPS outcome was assessed by the trail making test at 6\u201312 month postinjury in mild TBI. Fractional anisotropy (FA) features were extracted using a novel lesion\u2010load analytical strategy to capture spatially heterogeneous white matter injuries and minimize implicit assumptions of uniform injury across diverse clinical presentations. Acute mild TBI exhibited a general pattern of increased and decreased FA in specific white matter tracts. The power of acute FA measures to identify patients developing IPS deficits with 92% accuracy and further improved to 96% accuracy by adding inflammation cytokines. The classifiers predicted individual's IPS and working memory ratings (\n                    <jats:italic>r<\/jats:italic>\n                    =\u2009.74 and .80, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u2009.001). The thalamo\u2010cortical circuits and commissural tracts projecting or connecting frontal regions became important predictors. This prognostic model was also verified by an independent replicate sample. Our findings highlighted damage to frontal interhemispheric and thalamic projection fiber tracts harboring frontal\u2010subcortical neuronal circuits as a predictor for processing speed performance in mild TBI.\n                  <\/jats:p>","DOI":"10.1002\/hbm.25135","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T08:13:47Z","timestamp":1594628027000},"page":"4431-4441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Strategic white matter injury associated with long\u2010term information processing speed deficits in mild traumatic brain injury"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8790-5424","authenticated-orcid":false,"given":"Lijun","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering School of Life Science and Technology, Xi' an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering School of Life Science and Technology, Xi' an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Yang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering School of Life Science and Technology, Xi' an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuoqiu","family":"Gan","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering School of Life Science and Technology, Xi' an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-6877","authenticated-orcid":false,"given":"Xiaoyan","family":"Jia","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering School of Life Science and Technology, Xi' an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.7.2.220"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.08.015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.07.175"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr161"},{"key":"e_1_2_9_7_1","first-page":"1661","volume-title":"The 2006 IEEE international joint conference on neural network proceedings","author":"Cawley G. 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