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This allows us to investigate effects of pharmacological and nonpharmacological interventions on brain 5\u2010HT levels in living humans. Here, we study the neural responses to a visual stimulus using simultaneous PET\/MRI. In a cross\u2010over design, 11 healthy individuals were PET\/MRI scanned with the 5\u2010HT<jats:sub>1B<\/jats:sub> receptor radioligand [<jats:sup>11<\/jats:sup>C]AZ10419369, which is sensitive to changes in endogenous 5\u2010HT. During the last part of the scan, participants either viewed autobiographical images with positive valence (<jats:italic>n<\/jats:italic> = 11) or kept their eyes closed (<jats:italic>n<\/jats:italic> = 7). The visual stimuli increased cerebral blood flow (CBF) in the occipital cortex, as measured with pseudo\u2010continuous arterial spin labeling. Simultaneously, we found decreased 5\u2010HT<jats:sub>1B<\/jats:sub> receptor binding in the occipital cortex (\u22123.6\u2009\u00b1\u20093.6%), indicating synaptic 5\u2010HT release. Using a linear regression model, we found that the change in 5\u2010HT<jats:sub>1B<\/jats:sub> receptor binding was significantly negatively associated with change in CBF in the occipital cortex (<jats:italic>p<\/jats:italic> = .004). For the first time, we here demonstrate how cerebral 5\u2010HT levels change in response to nonpharmacological stimuli in humans, as measured with PET. Our findings more directly support a link between 5\u2010HT signaling and visual processing and\/or visual attention.<\/jats:p>","DOI":"10.1002\/hbm.25156","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T01:43:45Z","timestamp":1598579025000},"page":"4753-4763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Visual stimuli induce serotonin release in occipital cortex: A simultaneous positron emission tomography\/magnetic resonance imaging study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5564-7627","authenticated-orcid":false,"given":"Hanne Demant","family":"Hansen","sequence":"first","affiliation":[{"name":"Neurobiology Research Unit and NeuroPharm, Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital, Massachusetts  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