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We previously showed in monozygotic (MZ) twins associations between BW and brain morphology that were independent of genetics. In the present study, we employed a longitudinal MZ twin design to investigate whether variations in prenatal environment (as indexed by discordance in BW) are associated with resting\u2010state functional connectivity (rs\u2010FC) and with structural connectivity. We focused on the limbic and default mode networks (DMNs), which are key regions for emotion regulation and internally generated thoughts, respectively. One hundred and six healthy adolescent MZ twins (53 pairs; 42% male pairs) followed longitudinally from birth underwent a magnetic resonance imaging session at age 15. Graph theoretical analysis was applied to rs\u2010FC measures. TrackVis was used to determine track count as an indicator of structural connectivity strength. Lower BW twins had less efficient limbic network connectivity as compared to their higher BW co\u2010twin, driven by differences in the efficiency of the right hippocampus and right amygdala. Lower BW male twins had fewer tracks connecting the right hippocampus and right amygdala as compared to their higher BW male co\u2010twin. There were no associations between BW and the DMN. These findings highlight the possible role of unique prenatal environmental influences in the later development of efficient spontaneous limbic network connections within healthy individuals, irrespective of DNA sequence or shared environment.<\/jats:p>","DOI":"10.1002\/hbm.25188","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:37:07Z","timestamp":1599075427000},"page":"5228-5239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins"],"prefix":"10.1002","volume":"41","author":[{"given":"Dana A.","family":"Hayward","sequence":"first","affiliation":[{"name":"Sainte\u2010Justine Hospital Research Centre  Montreal Canada"},{"name":"Department of Psychology Concordia University  Montreal 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