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Yet brain reconfigurations at different spatial scales are seldom explored and whether they are associated with the neural aspects of brain disorders is far from understood. In this study, we introduced a dynamic measure called step\u2010wise functional network reconfiguration (sFNR) to characterize how brain configuration rewires at different spatial scales. We applied sFNR to two independent datasets, one includes 160 healthy controls (HCs) and 151 patients with schizophrenia (SZ) and the other one includes 314 HCs and 255 individuals with autism spectrum disorder (ASD). We found that both SZ and ASD have increased whole\u2010brain sFNR and sFNR between cerebellar and subcortical\/sensorimotor domains. At the ICN level, the abnormalities in SZ are mainly located in ICNs within subcortical, sensory, and cerebellar domains, while the abnormalities in ASD are more widespread across domains. Interestingly, the overlap SZ\u2010ASD abnormality in sFNR between cerebellar and sensorimotor domains was correlated with the reasoning\u2010problem\u2010solving performance in SZ (<jats:italic>r<\/jats:italic> =\u2009\u2212.1652, <jats:italic>p<\/jats:italic> =\u2009.0058) as well as the Autism Diagnostic Observation Schedule in ASD (<jats:italic>r<\/jats:italic> =\u2009.1853, <jats:italic>p<\/jats:italic> =\u2009.0077). Our findings suggest that dynamic reconfiguration deficits may represent a key intersecting point for SZ and ASD. The investigation of brain dynamics at different spatial scales can provide comprehensive insights into the functional reconfiguration, which might advance our knowledge of cognitive decline and other pathophysiology in brain disorders.<\/jats:p>","DOI":"10.1002\/hbm.25205","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T14:56:10Z","timestamp":1600872970000},"page":"80-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Dynamic functional network reconfiguration underlying the pathophysiology of schizophrenia and autism spectrum disorder"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1591-4900","authenticated-orcid":false,"given":"Zening","family":"Fu","sequence":"first","affiliation":[{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6837-5966","authenticated-orcid":false,"given":"Jing","family":"Sui","sequence":"additional","affiliation":[{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, Emory University  Atlanta Georgia USA"},{"name":"Chinese Academy of Sciences (CAS) Centre for Excellence in Brain Science and Intelligence Technology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Psychology Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0079-8177","authenticated-orcid":false,"given":"Yuhui","family":"Du","sequence":"additional","affiliation":[{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, Emory University  Atlanta Georgia USA"},{"name":"School of Computer and Information Technology Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Assaf","sequence":"additional","affiliation":[{"name":"Olin Neuropsychiatry Research Center, The Institute of Living  Hartford Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godfrey D.","family":"Pearlson","sequence":"additional","affiliation":[{"name":"Olin Neuropsychiatry Research Center, The Institute of Living  Hartford Connecticut USA"},{"name":"Department of Psychiatry Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vince D.","family":"Calhoun","sequence":"additional","affiliation":[{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2017.0161"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-017-0546-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs352"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a033321"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.079"},{"key":"e_1_2_9_7_1","unstructured":"Association AP(2013):Diagnostic and statistical manual of mental disorders (DSM\u20105\u00ae). 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