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Since deficits in dual\u2010task gait speed are associated with freezing of gait and gray matter atrophy, here we performed preplanned secondary analyses to answer two questions: (a) Do people with PD who are freezers present similar improvements compared to nonfreezers in DTC on gait speed with ABC\u2010C? (b) Can cortical thickness at baseline predict responsiveness to the ABC\u2010C? The DTC from 39 freezers and 43 nonfreezers who completed 6\u2009weeks of ABC\u2010C were analyzed. A subset of 51 participants (21 freezers and 30 nonfreezers) with high quality imaging data were used to characterize relationships between baseline cortical thickness and delta (\u0394) DTC on gait speed following ABC\u2010C. Freezers showed larger \u0394DTC on gait speed than nonfreezers with ABC\u2010C program (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Cortical thickness in visual and fronto\u2010parietal areas predicted \u0394DTC on gait speed in freezers, whereas sensorimotor\u2010lateral thickness predicted \u0394DTC on gait speed in nonfreezers (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). When matched for motor severity, visual cortical thickness was a common predictor of response to exercise in all individuals, presenting the largest effect size. In conclusion, freezers improved gait automaticity even more than nonfreezers from cognitively challenging exercise. DTC on gait speed improvement was associated with larger baseline cortical thickness from different brain areas, depending on freezing status, but visual cortex thickness showed the most robust relationship with exercise\u2010induced improvements in DTC.<\/jats:p>","DOI":"10.1002\/hbm.25211","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T18:24:15Z","timestamp":1602267855000},"page":"139-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cortical thickness as predictor of response to exercise in people with Parkinson's disease"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0244-6535","authenticated-orcid":false,"given":"Carla","family":"Silva\u2010Batista","sequence":"first","affiliation":[{"name":"Exercise Neuroscience Research Group University of S\u00e3o Paulo  SP Brazil"},{"name":"Department of Neurology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjanibhargavi","family":"Ragothaman","sequence":"additional","affiliation":[{"name":"Department of Neurology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Neurology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Carlson\u2010Kuhta","sequence":"additional","affiliation":[{"name":"Department of Neurology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Harker","sequence":"additional","affiliation":[{"name":"Department of Neurology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Hee","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"Department of Rehabilitation Medicine Seoul National University Boramae Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Nutt","sequence":"additional","affiliation":[{"name":"Department of Neurology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien A","family":"Fair","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neuroscience Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fay B.","family":"Horak","sequence":"additional","affiliation":[{"name":"Department of Neurology Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"Veterans Affairs Portland Health Care System (VAPORHCS)  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Miranda\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neuroscience Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00224065.2005.11980315"},{"issue":"2","key":"e_1_2_9_3_1","first-page":"147","article-title":"Visuo\u2010cognitive dysfunctions in Parkinson's disease","volume":"5","author":"Antal A.","year":"1998","journal-title":"Clinical Neuroscience"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.07.024"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00089.2015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22994"},{"key":"e_1_2_9_7_1","first-page":"29","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968314567150"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2004.11.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","unstructured":"DCAN\u2010Labs. 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