{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:56:03Z","timestamp":1787907363703,"version":"build-2784847793"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SU 922\/1\u20131"],"award-info":[{"award-number":["SU 922\/1\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WO1425\/6\u20131"],"award-info":[{"award-number":["WO1425\/6\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DZ 78\/1\u20131"],"award-info":[{"award-number":["DZ 78\/1\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pharyngolaryngeal hypesthesia is a major reason for dysphagia in various neurological diseases. Emerging neuromodulation devices have shown potential to foster dysphagia rehabilitation, but the optimal treatment strategy is unknown. Because functional imaging studies are difficult to conduct in severely ill patients, we induced a virtual sensory lesion in healthy volunteers and evaluated the effects of central and peripheral neurostimulation techniques. In a sham\u2010controlled intervention study with crossover design on 10 participants, we tested the potential of (peripheral) pharyngeal electrical stimulation (PES) and (central) transcranial direct current stimulation (tDCS) to revert the effects of lidocaine\u2010induced pharyngolaryngeal hypesthesia on central sensorimotor processing. Changes were observed during pharyngeal air\u2010pulse stimulation and voluntary swallowing applying magnetoencephalography before and after the interventions. PES induced a significant (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; .05) increase of activation during swallowing in the bihemispheric sensorimotor network in alpha and low gamma frequency ranges, peaking in the right premotor and left primary sensory area, respectively. With pneumatic stimulation, significant activation increase was found after PES in high gamma peaking in the left premotor area. Significant changes of brain activation after tDCS could neither be detected for pneumatic stimulation nor for swallowing. Due to the peripheral cause of dysphagia in this model, PES was able to revert the detrimental effects of reduced sensory input on central processing, whereas tDCS was not. Results may have implications for therapeutic decisions in the clinical context.\n                  <\/jats:p>","DOI":"10.1002\/hbm.25233","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T06:55:45Z","timestamp":1602917745000},"page":"427-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Targeting the sensory feedback within the swallowing network\u2014Reversing artificially induced pharyngolaryngeal hypesthesia by central and peripheral stimulation strategies"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0865-0297","authenticated-orcid":false,"given":"Paul","family":"Muhle","sequence":"first","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology University Hospital Muenster  Muenster Germany"},{"name":"Institute for Biomagnetism and Biosignalanalysis University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bendix","family":"Labeit","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology University Hospital Muenster  Muenster Germany"},{"name":"Institute for Biomagnetism and Biosignalanalysis University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wollbrink","sequence":"additional","affiliation":[{"name":"Institute for Biomagnetism and Biosignalanalysis University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Claus","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Warnecke","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten H.","family":"Wolters","sequence":"additional","affiliation":[{"name":"Institute for Biomagnetism and Biosignalanalysis University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Gross","sequence":"additional","affiliation":[{"name":"Institute for Biomagnetism and Biosignalanalysis University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Dziewas","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Suntrup\u2010Krueger","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology University Hospital Muenster  Muenster Germany"},{"name":"Institute for Biomagnetism and Biosignalanalysis University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.5.855"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(96)00011-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949610500202"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02657.2000"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.01.037"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-019-09980-1"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02407397"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2016.04.027"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-3057(96)80023-1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30255-2"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/35094565"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00399.2002"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135603"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.034"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.02.041"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.05.017"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050133"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.88.3.1400"},{"issue":"1","key":"e_1_2_12_20_1","first-page":"G219","article-title":"Cortical activation during human volitional swallowing: An event\u2010related fMRI study","volume":"277","author":"Hamdy S.","year":"1999","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.4.1917"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.012"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200302100-00024"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90391-0"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.1.7509247"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.01.404"},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","unstructured":"Khan A. Haueisen J. Wolters C. H. Antonakakis M. Vogenauer N. Wollbrink A. \u2026Paulus W.(2019).Constrained maximum intensity optimized multi\u2010electrode tDCS targeting of human somatosensory network. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference 2019 5894\u20135897. doi:https:\/\/doi.org\/10.1109\/EMBC.2019.8857253","DOI":"10.1109\/EMBC.2019.8857253"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13690"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.176214"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.04.234"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-012-3069-9"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31829caf33"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20743"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479483"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.03.024"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.2.938"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32832b255e"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22597"},{"issue":"8","key":"e_1_2_12_39_1","first-page":"1520","article-title":"Lateralization of cortical function in swallowing: A functional MR imaging study","volume":"20","author":"Mosier K. M.","year":"1999","journal-title":"AJNR. American Journal of Neuroradiology"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487037"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000482002"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40141-018-0201-1"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2478"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/48\/22\/002"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-013-9504-7"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/156869"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(00)00235-2"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12916"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006667"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2626(03)00277-X"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.04.012"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-019-10001-4"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/026921559701100111"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-6-8"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12670"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3897-8"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.06.055"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.10.016"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12783"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13307"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25151"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25151"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.024643"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20488"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-8-62"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-76"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019987"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.263475"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1137\/15M1026481"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31828a4626"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101685"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000523"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00342-3"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.25233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T20:52:28Z","timestamp":1693687948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.25233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,17]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/hbm.25233"],"URL":"https:\/\/doi.org\/10.1002\/hbm.25233","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,17]]},"assertion":[{"value":"2020-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}