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Twenty\u2010four patients with acute tinnitus, 23 patients with chronic tinnitus, and 32 healthy controls were recruited. High\u2010density electroencephalography (EEG) was used to explore changes in brain areas and functional connectivity in different groups. When compared with healthy subjects, acute tinnitus patients had a significant reduction in superior frontal cortex activity across all frequency bands, whereas chronic tinnitus patients had a significant reduction in the superior frontal cortex at beta 3 and gamma frequency bands as well as a significant increase in the inferior frontal cortex at delta\u2010band and superior temporal cortex at alpha 1 frequency band. When compared to the chronic tinnitus group, the acute tinnitus group activity was significantly increased in the middle frontal and parietal gyrus at the gamma\u2010band. Functional connectivity analysis showed that the chronic tinnitus group had increased connections between the parahippocampus gyrus, posterior cingulate cortex, and precuneus when compared with the healthy group. Alterations of local brain activity and connections between the parahippocampus gyrus and other nonauditory areas appeared in the transition from acute to chronic tinnitus. This indicates that the appearance and development of tinnitus is a dynamic process involving aberrant local neural activity and abnormal connectivity in multifunctional brain networks.<\/jats:p>","DOI":"10.1002\/hbm.25238","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T17:36:14Z","timestamp":1602610574000},"page":"485-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-1443","authenticated-orcid":false,"given":"Liping","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Sun Yat\u2010sen Memorial Hospital, Sun Yat\u2010sen University  Guangzhou City Guangdong Province China"},{"name":"Institute of Hearing and Speech\u2010Language Science Sun 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