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Here, we apply a meta\u2010analytic estimation approach to neuroimaging studies (\n                    <jats:italic>N<\/jats:italic>\n                    =\u200923; subjects = 316) and ask whether SL comprehension in deaf signers relies on the same primarily left\u2010hemispheric cortical network implicated in spoken and written language (SWL) comprehension in hearing speakers. We show that: (a) SL recruits bilateral fronto\u2010temporo\u2010occipital regions with strong left\u2010lateralization in the posterior inferior frontal gyrus known as Broca's area, mirroring functional asymmetries observed for SWL. (b) Within this SL network, Broca's area constitutes a hub which attributes abstract linguistic information to gestures. (c) SL\u2010specific voxels in Broca's area are also crucially involved in SWL, as confirmed by meta\u2010analytic connectivity modeling using an independent large\u2010scale neuroimaging database. This strongly suggests that the human brain evolved a lateralized language network with a supramodal hub in Broca's area which computes linguistic information independent of speech.\n                  <\/jats:p>","DOI":"10.1002\/hbm.25254","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T02:09:57Z","timestamp":1603937397000},"page":"699-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Functional neuroanatomy of language without speech: An ALE meta\u2010analysis of sign language"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2233-6720","authenticated-orcid":false,"given":"Patrick C.","family":"Trettenbrein","sequence":"first","affiliation":[{"name":"Department of Neuropsychology Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany"},{"name":"International Max Planck Research School on Neuroscience of 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