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We studied 64 patients with idiopathic tinnitus, including 29 patients who were categorized into an effective group (EG) and 35 who were categorized into an ineffective group (IG) according to the 6\u2010month follow\u2010up improvement of the Tinnitus Handicap Inventory score, along with 63 healthy controls (HCs). All participants underwent structural and diffusion tensor imaging scanning on a 3\u2010T magnetic resonance system. Differences in brain gray\/white matter volume and white matter microstructure were evaluated using voxel\u2010based morphometry analysis and tract\u2010based spatial statistics among the three groups. Associations between brain reorganization and the improvement of tinnitus symptoms were also investigated. Compared with EG patients, IG patients experienced a significant gray matter volume decrease in the right middle frontal gyrus (MFG)\/right precentral gyrus (PreCG). Meanwhile, both EG and IG patients showed significant changes (decrease or increase) in brain white matter integrity in the auditory\u2010related or nonauditory\u2010related white matter fiber tracts compared with HCs, while EG patients showed decreased axial diffusivity in the bilateral middle cerebellar peduncle (MCP) compared with IG patients. We combined the gray matter change of the MFG\/PreCG and the white matter integrity of the bilateral MCP as an imaging indicator to evaluate the patient's prognosis and screen patients before treatment; this approach reached a sensitivity of 77.1% and a specificity of 82.8%. Our study suggests that there was a close relationship between brain reorganization and tinnitus improvement. The right MFG\/PreCG and bilateral MCP may be indicators that can be used to predict prognoses in patients with idiopathic tinnitus and may be used to screen patients before sound therapy. These findings may provide new useful information that can lead to a better understanding of the tinnitus mechanism.<\/jats:p>","DOI":"10.1002\/hbm.25260","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T12:29:02Z","timestamp":1603542542000},"page":"753-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Outcomes at 6\u2009months are related to brain structural and white matter microstructural reorganization in idiopathic tinnitus patients treated with sound therapy"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-9647","authenticated-orcid":false,"given":"Qian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital, Capital Medical University  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital, Capital Medical University  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaodi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Friendship Hospital, Capital Medical University  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital, Capital Medical University  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital, Capital Medical University  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital, Capital Medical University  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusheng","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Friendship Hospital, Capital Medical University  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-6469","authenticated-orcid":false,"given":"Zhenchang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital, Capital Medical University  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.05.013"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00221"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.1700"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1136"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JIN-180090"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00591"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.06576"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.03.021"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.08.010"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00059"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00614"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26796"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1716016"},{"key":"e_1_2_11_16_1","first-page":"CD010151","article-title":"Amplification with hearing aids for patients with tinnitus and co\u2010existing hearing loss","volume":"1","author":"Hoare D. 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