{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T14:41:18Z","timestamp":1764859278696,"version":"3.40.5"},"reference-count":78,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2021,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nociceptive signals are processed within a pain\u2010related network of the brain. Migraine is a rather specific model to gain insight into this system. Brain networks may be described by white matter tracts interconnecting functionally defined gray matter regions. Here, we present an overview of the migraine\u2010related pain network revealed by this strategy. Based on diffusion tensor imaging data from subjects in the Human Connectome Project (HCP) database, we used a global tractography approach to reconstruct white matter tracts connecting brain regions that are known to be involved in migraine\u2010related pain signaling. This network includes an ascending nociceptive pathway, a descending modulatory pathway, a cortical processing system, and a connection between pain\u2010processing and modulatory areas. The insular cortex emerged as the central interface of this network. Direct connections to visual and auditory cortical association fields suggest a potential neural basis of phono\u2010 or photophobia and aura phenomena. The intra\u2010axonal volume (V<jats:sub>intra<\/jats:sub>) as a measure of fiber integrity based on diffusion microstructure was extracted using an innovative supervised machine learning approach in form of a Bayesian estimator. Self\u2010reported pain levels of HCP subjects were positively correlated with tract integrity in subcortical tracts. No correlation with pain was found for the cortical processing systems.<\/jats:p>","DOI":"10.1002\/hbm.25261","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T15:40:58Z","timestamp":1603899658000},"page":"766-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Approximation to pain\u2010signaling network in humans by means of migraine"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7696-9334","authenticated-orcid":false,"given":"Jonas Aurel","family":"Hosp","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Neurology and Neuroscience Medical Center \u2013 University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2742-1940","authenticated-orcid":false,"given":"Marco","family":"Reisert","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Stereotactic and Functional Neurosurgery University of Freiburg  Freiburg Germany"},{"name":"Department of Medical Physics Freiburg University Medical Center  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"von Kageneck","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Neurology and Neuroscience Medical Center \u2013 University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Rijntjes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Neurology and Neuroscience Medical Center \u2013 University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius","family":"Weiller","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Neurology and Neuroscience Medical Center \u2013 University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0943-13.2013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.1111"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh236"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(03)00172-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2012.8.2.89"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-011-0322-8"},{"volume-title":"Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipien dargestellt aufgrund des Zellenbaues","year":"1909","author":"Brodmann K.","key":"e_1_2_9_8_1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.05.010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30435-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415573513"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17740794"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182872e80"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(89)90025-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3182588293"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13645"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22565"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04268-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24770"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv308"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000052998.58526.A9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.127"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"e_1_2_9_24_1","first-page":"1","volume-title":"The international classification of headache disorders","author":"Headache Classification Committee of the International Headache Society (IHS)","year":"2018"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90064-4"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1994.1406401.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-010-2340-1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0060-18.2018"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10978"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.107591"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00071"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1983.50.6.1479"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00014"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417752120"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.3.537"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.10.005"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-016-0016-y"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13937"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00468.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-2866-0"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17722109"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0262-0"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1647-17.2017"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.781"},{"key":"e_1_2_9_46_1","first-page":"159","article-title":"Neurovascular and molecular mechanisms in migraine headaches","volume":"5","author":"Moskowitz M. A.","year":"1993","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.084"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.07.021"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316944111"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2018.06.007"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183717"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1071-3"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419885392"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq146"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411430263"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.09.058"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.016"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.12.2490"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3758\/CABN.2.3.264"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.04.006"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200011000-00005"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww097"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25697"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.01.086"},{"key":"e_1_2_9_65_1","first-page":"248","volume":"26","author":"Schwedt T. J.","year":"2013","journal-title":"Multisensory integration in migraine: Current Opinion in Neurology"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.12.7121"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12074"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4496-10.2011"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0699-5"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq011"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1707733.x"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.1998.1805243.x"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204471"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.042"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0795-658"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00621.x"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082164"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.072"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.2017"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.25261","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T08:17:52Z","timestamp":1693729072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.25261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2,15]]}},"alternative-id":["10.1002\/hbm.25261"],"URL":"https:\/\/doi.org\/10.1002\/hbm.25261","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"type":"print","value":"1065-9471"},{"type":"electronic","value":"1097-0193"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"assertion":[{"value":"2020-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}