{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:37:03Z","timestamp":1792154223935,"version":"4.4.0"},"reference-count":92,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rumination, repetitively thinking about the causes, consequences, and one's negative affect, has been considered as an important factor of depression. The intrusion of ruminative thoughts is not easily controlled, and it may be useful to visualize one's neural activity related to rumination and to use that information to facilitate one's self\u2010control. Real\u2010time fMRI neurofeedback (rtfMRI\u2010nf) enables one to see and regulate the fMRI signal from their own brain. This proof\u2010of concept study utilized connectivity\u2010based rtfMRI\u2010nf (cnf) to normalize brain functional connectivity (FC) associated with rumination. Healthy participants were instructed to brake or decrease FC between the precuneus and the right temporoparietal junction (rTPJ), associated with high levels of rumination, while engaging in a self\u2010referential task. The cnf group (\n                    <jats:italic>n<\/jats:italic>\n                    = 14) showed a linear decrease in the precuneus\u2010rTPJ FC across neurofeedback training (trend [112] = \u22120.180, 95% confidence interval [CI] \u22120.330 to \u22120.031, while the sham group (\n                    <jats:italic>n<\/jats:italic>\n                    = 14) showed a linear increase in the target FC (trend [112] = 0.151, 95% CI 0.017 to 0.299). Although the cnf group showed a greater reduction in state\u2010rumination compared to the sham group after neurofeedback training (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05), decoupled precuneus\u2010rTPJ FC did not predict attenuated state\u2010rumination. We did not find any significant aversive effects of rtfMRI\u2010nf in all study participants. These results suggest that cnf has the capacity to influence FC among precuneus and rTPJ of a ruminative brain circuit. This approach can be applied to mood and anxiety patients to determine the clinical benefits of reduction in maladaptive rumination.\n                  <\/jats:p>","DOI":"10.1002\/hbm.25268","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T15:41:45Z","timestamp":1605022905000},"page":"922-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prevent breaking bad: A proof of concept study of rebalancing the brain's rumination circuit with real\u2010time\n                    <scp>fMRI<\/scp>\n                    functional connectivity neurofeedback"],"prefix":"10.1002","volume":"42","author":[{"given":"Aki","family":"Tsuchiyagaito","sequence":"first","affiliation":[{"name":"Laureate Institute for Brain Research  Tulsa Oklahoma USA"},{"name":"Japan Society for the Promotion of Science  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Misaki","sequence":"additional","affiliation":[{"name":"Laureate Institute for Brain Research  Tulsa Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obada Al","family":"Zoubi","sequence":"additional","affiliation":[{"name":"Laureate Institute for Brain Research  Tulsa Oklahoma USA"},{"name":"Department of Electrical and Computer Engineering University of Oklahoma  Tulsa Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Tulsa 1000 Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Paulus","sequence":"additional","affiliation":[{"name":"Laureate Institute for Brain Research  Tulsa Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0053-9746","authenticated-orcid":false,"given":"Jerzy","family":"Bodurka","sequence":"additional","affiliation":[{"name":"Laureate Institute for Brain Research  Tulsa Oklahoma USA"},{"name":"Stephenson School of Biomedical Engineering University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.02.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90005-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.11.059"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2007.05.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330213"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.022"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2414"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.08.041"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0634-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00573"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1521\/ijct.2008.1.3.192"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2020.00060"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(200002)43:2<259::AID-MRM13>3.0.CO;2-P"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200007)44:1<162::aid-mrm23>3.0.co;2-e"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.85.2.348"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718003835"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.04.246"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-10321-6.00003-5"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10608-008-9191-0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-008-9152-9"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00802"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv311"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.010"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-0629-1_6"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1981.tb01826.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5626-10.2011"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.5127\/jep.029112"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v069.i01"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.11.007"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968315619699"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00390"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.068"},{"key":"e_1_2_10_38_1","volume-title":"Manual for the profile of mood states (POMS)","author":"McNair D.","year":"1971"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00160"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0126-5"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.08.033"},{"key":"e_1_2_10_42_1","volume-title":"Comprehensive fMRI real\u2010time processing improves online functional connectivity evaluation","author":"Misaki M.","year":"2019"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.08.025"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102244"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.128.4.638"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102191"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.07.014"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1018769531641"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843x.109.3.504"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.61.1.115"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-6924.2008.00088.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116107"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.10.044"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.12.006"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.7554\/elife.28974"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.001"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.264.19.2511"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1018713313894"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa009"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00230-1"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116684"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.02.057"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0021-843x.111.2.350"},{"issue":"20","key":"e_1_2_10_65_1","first-page":"22","article-title":"The Mini\u2010international neuropsychiatric interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheehan D. V.","year":"1998","journal-title":"The Journal of Clinical Psychiatry"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812686106"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1212003"},{"key":"e_1_2_10_68_1","volume-title":"The behavior of organisms: An experimental analysis","author":"Skinner B. F.","year":"1938"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2008.10.003"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.11.004"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1037\/1528-3542.1.1.25"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2017.01.032"},{"key":"e_1_2_10_73_1","volume-title":"Manual for the state\u2010trait anxiety inventory","author":"Spielberger C. D.","year":"1983"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2018.04.002"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721572115"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016620"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2015.01.020"},{"key":"e_1_2_10_78_1","volume-title":"Rumination\u2010focused cognitive\u2010behavioral therapy for depression","author":"Watkins E. R.","year":"2018"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.090282"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2007.02.007"},{"key":"e_1_2_10_81_1","first-page":"9","article-title":"Comorbidity and mixed anxiety\u2010depressive disorders: Is there epidemiologic evidence?","volume":"54","author":"Wittchen H. U.","year":"1993","journal-title":"The Journal of Clinical Psychiatry"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx059"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx177"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16060637"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12665"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088785"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914826107"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2014.0262"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496057"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116287"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024522"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.04.010"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079184"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.25268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:34:27Z","timestamp":1765434867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.25268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,10]]},"references-count":92,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/hbm.25268"],"URL":"https:\/\/doi.org\/10.1002\/hbm.25268","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,10]]},"assertion":[{"value":"2020-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}