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Such real\u2010world tasks are relevant to characterize longitudinal brain reorganization poststroke, and removal of TCM artifacts is vital for improved clinical interpretation and translation. In this study, we developed a novel independent component analysis (ICA)\u2010based approach to denoise spatio\u2010temporally varying TCM artifacts in 14 persons with aphasia who participated in an overt language fMRI paradigm. We compared the new methodology with other existing approaches such as \u201cstandard\u201d volume registration, nonselective motion correction ICA packages (i.e., AROMA), and combining the novel approach with AROMA. Results show that the proposed methodology outperforms other approaches in removing TCM\u2010related false positive activity (i.e., improved detectability power) with high spatial specificity. The proposed method was also effective in maintaining a balance between removal of TCM\u2010related trial\u2010by\u2010trial variability and signal retention. Finally, we show that the TCM artifact is related to clinical metrics, such as speech fluency and aphasia severity, and the implication of TCM denoising on such relationship is also discussed. Overall, our work suggests that routine bulkhead motion based denoising packages cannot effectively account for spatio\u2010temporally varying TCM. Further, the proposed TCM denoising approach requires a one\u2010time front\u2010end effort to hand label and train the classifiers that can be cost\u2010effectively utilized to denoise large clinical data sets.<\/jats:p>","DOI":"10.1002\/hbm.25280","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T16:27:57Z","timestamp":1605803277000},"page":"1116-1129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A method to mitigate spatio\u2010temporally varying task\u2010correlated motion artifacts from overt\u2010speech\n                    <scp>fMRI<\/scp>\n                    paradigms in aphasia"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0946-2311","authenticated-orcid":false,"given":"Venkatagiri","family":"Krishnamurthy","sequence":"first","affiliation":[{"name":"Center for Visual and Neurocognitive Rehabilitation Atlanta VAMC  Decatur Georgia USA"},{"name":"Department of Medicine, Division of Geriatrics and Gerontology Emory University  Atlanta Georgia USA"},{"name":"Department of Neurology Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa C.","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Center for Visual and Neurocognitive Rehabilitation Atlanta VAMC  Decatur Georgia USA"},{"name":"Department of Physics &amp; Astronomy Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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