{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:36:35Z","timestamp":1781634995445,"version":"3.54.5"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The perception of pain to noxious stimuli, also known as pain sensitivity, varies among individuals. The comprised brain structures and their white matter pathways are complex and elusive. Here, we aimed to investigate whether variation of microstructure of the medial forebrain bundle (MFB), a tract connecting the basal forebrain with the brain stem, is associated with interindividual pain sensitivity. We assessed interindividual pain sensitivity as a rating of pain intensity to heat stimuli (45, 47, and 48.9\u00b0C) in 38 healthy men (age: 27.05\u2009\u00b1\u20095.7\u2009years). We also reconstructed the MFB using multitensor tractography from diffusion magnetic resonance imaging (dMRI) and calculated free\u2010water corrected dMRI measures of fractional anisotropy (FA\n                    <jats:sub>t<\/jats:sub>\n                    ), radial diffusivity (RD\n                    <jats:sub>t<\/jats:sub>\n                    ), and axial diffusivity (AD\n                    <jats:sub>t<\/jats:sub>\n                    ). Lower ratings of interindividual pain intensity correlated with higher FA\n                    <jats:sub>t<\/jats:sub>\n                    and lower RD\n                    <jats:sub>t<\/jats:sub>\n                    of the MFB. As changes in FA\n                    <jats:sub>t<\/jats:sub>\n                    and RD\n                    <jats:sub>t<\/jats:sub>\n                    may reflect abnormalities in myelination, the results might be interpreted as that a lower pain rating is associated with higher degree of myelination of the MFB and could represent an inhibitory pathway of pain. Our results suggest that alteration of microstructure in the MFB contributes to the interindividual variation of pain perception.\n                  <\/jats:p>","DOI":"10.1002\/hbm.25281","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T17:36:52Z","timestamp":1605029812000},"page":"1130-1137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Microstructural alterations in medial forebrain bundle are associated with\n                    <scp>interindividual<\/scp>\n                    pain sensitivity"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0321-2119","authenticated-orcid":false,"given":"Maria","family":"Geisler","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology Friedrich\u2010Schiller\u2010University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rizzoni","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry Brigham and Women's Hospital, and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Makris","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry Brigham and Women's Hospital, and Harvard Medical School  Boston Massachusetts USA"},{"name":"Departments of Radiology and Psychiatry Harvard Medical School  Boston Massachusetts USA"},{"name":"Departments of Radiology and Psychiatry Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Pasternak","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry Brigham and Women's Hospital, and Harvard Medical School  Boston Massachusetts USA"},{"name":"Departments of Radiology and Psychiatry Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9946-2314","authenticated-orcid":false,"given":"Yogesh","family":"Rathi","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry Brigham and Women's Hospital, and Harvard Medical School  Boston Massachusetts USA"},{"name":"Departments of Radiology and Psychiatry Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Bouix","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry Brigham and Women's Hospital, and Harvard Medical School  Boston Massachusetts USA"},{"name":"Departments of Radiology and Psychiatry Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Herbsleb","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine and Health Promotion Friedrich\u2010Schiller\u2010University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-5679","authenticated-orcid":false,"given":"Karl\u2010J\u00fcrgen","family":"B\u00e4r","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine University Hospital Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Friedrich\u2010Schiller\u2010University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zora","family":"Kikinis","sequence":"additional","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry Brigham and Women's Hospital, and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181f85ed2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-011-9297-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3153"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1996.0086"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2466\/02.09.22.PMS.112.3.926-946"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.06.041"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.02.042"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22836"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.08.013"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2008.05.004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4184-08.2009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.11080180"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.03.019"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000171862.17301.84"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.032"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001590"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32930"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2008.12.009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-010-2340-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201809575"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmr.a.20049"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.095"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2010.2048121"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.044"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2217\/fnl.14.57"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.043"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.06.008"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.04.004"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43766"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22055"},{"key":"e_1_2_7_36_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2017"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S33925"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00258-9"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.03.025"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3381"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2020.00040"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.030"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2412"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-018-0033-8"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.07.005"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.01.028"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.07.010"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.012"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww100"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078663"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204471"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1179-4"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8934"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20689"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002036"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2011-100386"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24579"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213952"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.25281","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.25281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:34:08Z","timestamp":1765434848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.25281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,10]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/hbm.25281"],"URL":"https:\/\/doi.org\/10.1002\/hbm.25281","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,10]]},"assertion":[{"value":"2020-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}