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This study characterized white matter in mFND patients compared to healthy controls (HCs), and investigated associations between fiber bundle integrity and cardiac interoception. Voxel\u2010based analysis and tractography quantified fractional anisotropy (FA) in 38 mFND patients compared to 38 HCs. Secondary analyses compared functional seizures (FND\u2010seiz;<jats:italic>n<\/jats:italic>= 21) or functional movement disorders (<jats:italic>n<\/jats:italic>= 17) to HCs. Network lesion mapping identified gray matter origins of implicated fiber bundles. Within\u2010group mFND analyses investigated relationships between FA, heartbeat tracking accuracy and interoceptive trait prediction error (discrepancies between interoceptive accuracy and self\u2010reported bodily awareness). Results were corrected for multiple comparisons, and all findings were adjusted for depression and trait anxiety. mFND and HCs did not show any between\u2010group interoceptive accuracy or FA differences. However, the FND\u2010seiz subgroup compared to HCs showed decreased integrity in right\u2010lateralized tracts: extreme capsule\/inferior fronto\u2010occipital fasciculus, arcuate fasciculus, inferior longitudinal fasciculus, and thalamic\/striatum to occipital cortex projections. These alterations originated predominantly from the right temporoparietal junction and inferior temporal gyrus. In mFND patients, individual differences in interoceptive accuracy and interoceptive trait prediction error correlated with fiber bundle integrity originating from the insula, temporoparietal junction, putamen and thalamus among other regions. In this first study investigating brain\u2010interoception relationships in mFND, individual differences in interoceptive accuracy and trait prediction error mapped onto multimodal integration\u2010related fiber bundles. Right\u2010lateralized limbic and associative tract disruptions distinguished FND\u2010seiz from HCs.<\/jats:p>","DOI":"10.1002\/hbm.25304","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T13:52:04Z","timestamp":1607349124000},"page":"1434-1445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A<scp>DTI<\/scp>study"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7594-7093","authenticated-orcid":false,"given":"Petr","family":"Sojka","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine Masaryk University Brno and University Hospital, Brno Brno Czech Republic"},{"name":"Department of Psychology and Psychosomatics, Faculty of Medicine Masaryk University and University Hospital Brno Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibai","family":"Diez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Functional Neurological Disorder Research Program, Behavioral Neurology Unit, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA"},{"name":"Athinoula A. 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